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5-HT1A基因与脑源性神经营养因子（BDNF）基因之间的相互作用会增加难治性抑郁症的风险。

Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression.

作者信息

Anttila S, Huuhka K, Huuhka M, Rontu R, Hurme M, Leinonen E, Lehtimäki T

机构信息

Medical School, University of Tampere, Tampere, Finland.

出版信息

J Neural Transm (Vienna). 2007;114(8):1065-8. doi: 10.1007/s00702-007-0705-9. Epub 2007 Mar 31.

DOI:10.1007/s00702-007-0705-9
PMID:17401528
Abstract

Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.

摘要

多项研究已将5-HT1A C1019G和脑源性神经营养因子（BDNF）G196A（Val66Met）基因多态性与重度抑郁症（MDD）及抗抑郁药的作用联系起来。我们试图证明5-HT1A和BDNF多态性之间的相互作用可预测难治性抑郁症的风险。样本包括119例难治性MDD患者和392例对照。对5-HT1A C1019G和BDNF G196A（Val66Met）多态性进行了研究。5-HT1A GG与BDNF GA + AA基因型的组合与抑郁症风险增加相关。

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