Ribeiro Luciana, Busnello João V, Cantor Rita M, Whelan Fiona, Whittaker Pamela, Deloukas Panos, Wong Ma-Li, Licinio Julio
Department of Psychiatry & Behavioral Sciences, Center on Pharmacogenomics, University of Miami Miller School of Medicine, Miami, Florida 33136-1013, USA.
Neuroreport. 2007 Aug 6;18(12):1291-3. doi: 10.1097/WNR.0b013e328273bcb0.
The hypothesis that brain-derived neurotrophic factor (BDNF) is involved in the pathogenesis of major depression is supported by several research findings; however, genetic studies assessing the relationship between BDNF and psychiatric disorders have produced conflicting results. We examined the effect of a BDNF polymorphism on depression susceptibility in Mexican-Americans. The single nucleotide polymorphism (Val66Met), which has been shown to have functional and behavioral effects, was genotyped in 284 depressed participants and 331 controls, showing association with depression (P=0.005). Individuals homozygous for the major allele (GG) had an increased chance of being depressed (OR=1.7 95% CI 1.17-2.47). Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans.
脑源性神经营养因子（BDNF）参与重度抑郁症发病机制的假说得到了多项研究结果的支持；然而，评估BDNF与精神疾病之间关系的基因研究产生了相互矛盾的结果。我们研究了BDNF基因多态性对墨西哥裔美国人抑郁症易感性的影响。对284名抑郁症患者和331名对照者进行了单核苷酸多态性（Val66Met）基因分型，该多态性已被证明具有功能和行为效应，结果显示其与抑郁症有关联（P=0.005）。主要等位基因（GG）纯合的个体患抑郁症的几率增加（OR=1.7，95%CI 1.17-2.47）。我们的研究结果支持BDNF单核苷酸多态性rs6265与抑郁症的关联，表明这种多态性可能增加墨西哥裔美国人患重度抑郁症的易感性。
