Huuhka Kaija, Anttila Sami, Huuhka Martti, Leinonen Esa, Rontu Riikka, Mattila Kari, Lehtimäki Terho
Medical School, University of Tampere, 33014 Tampere, Finland.
Eur Arch Psychiatry Clin Neurosci. 2007 Feb;257(1):31-5. doi: 10.1007/s00406-006-0679-x.
The aim of the present study was to examine an association of brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T and the response to electroconvulsive therapy (ECT) in major depressive disorder (MDD). The study group consisted of 119 patients consecutively admitted for ECT in the Department of Psychiatry, Tampere University Hospital. All patients fulfilled the diagnostic criteria of DSM-IV for MDD. ECT was administered three times a week with a brief pulse constant current device. The Montgomery and Asberg Depression Rating Scale (MADRS) was used as an outcome measure of depression. Genotyping was performed using fluorescent allele-specific TaqMan probes. No association between either G196A or C270T and the response to ECT was found in the whole population. There were no significant differences in responses between men and women or between psychotic and non-psychotic patients. However, within subgroups such as in psychotic and in late-onset depression CC genotype of C270T may predict good response. BDNF may not be associated with response to ECT in general, but some association in subgroups may exist.
本研究旨在探讨脑源性神经营养因子（BDNF）基因多态性G196A和C270T与重度抑郁症（MDD）患者电休克治疗（ECT）反应之间的关联。研究组由坦佩雷大学医院精神科连续收治的119例接受ECT治疗的患者组成。所有患者均符合DSM-IV中MDD的诊断标准。使用短暂脉冲恒流装置每周进行3次ECT治疗。采用蒙哥马利-阿斯伯格抑郁评定量表（MADRS）作为抑郁的疗效指标。使用荧光等位基因特异性TaqMan探针进行基因分型。在整个人群中未发现G196A或C270T与ECT反应之间存在关联。男性与女性之间或精神病性与非精神病性患者之间的反应无显著差异。然而，在精神病性和晚发性抑郁症等亚组中，C270T的CC基因型可能预示着良好的反应。总体而言，BDNF可能与ECT反应无关，但在亚组中可能存在一些关联。
