Hu Zhiping, Zeng Liuwang, Huang Zhiling, Zhang Jie, Li Ting
Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, China.
Neurochem Res. 2007 Aug;32(8):1265-77. doi: 10.1007/s11064-007-9302-4. Epub 2007 Mar 31.
Alzheimer's disease is an irreversible, progressive neurodegenerative disorder leading invariably to death, usually within 7-10 years after diagnosis and is the leading cause of dementia in the elderly. Not only is Alzheimer's disease a tragic disease in which people suffer from neurodegeneration in the years to come, it also becomes an incredible burden on the public health system. However, there is currently no effective treatment to halt the progression or prevent the onset of Alzheimer's disease. This is partly due to the fact that the complex pathophysiology of Alzheimer's disease is not yet completely understood. Recently, Golgi apparatus is found to play an important role in Alzheimer's disease. In this review, we discuss the changes of Golgi apparatus during clinical progression and pathological development of Alzheimer's disease. First, changes of Golgi apparatus size in Alzheimer's disease are summarized. We then address the role of Golgi apparatus in the neuropathology of Alzheimer's disease. Finally, the role of Golgi apparatus in the pathogenesis of Alzheimer's disease is discussed. Understanding the contribution of Golgi apparatus dysfunction to Alzheimer's disease and its pathophysiological basis will significantly impact our ability to develop more effective therapies for Alzheimer's disease.
阿尔茨海默病是一种不可逆转的、进行性神经退行性疾病，最终必然导致死亡，通常在确诊后7至10年内，它是老年人痴呆症的主要病因。阿尔茨海默病不仅是一种悲剧性疾病，患者在未来数年里会遭受神经退行性变，它也给公共卫生系统带来了巨大负担。然而，目前尚无有效的治疗方法来阻止阿尔茨海默病的进展或预防其发病。部分原因在于阿尔茨海默病复杂的病理生理学尚未完全被理解。最近，发现高尔基体在阿尔茨海默病中起重要作用。在本综述中，我们讨论了阿尔茨海默病临床进展和病理发展过程中高尔基体的变化。首先，总结了阿尔茨海默病中高尔基体大小的变化。然后，我们阐述了高尔基体在阿尔茨海默病神经病理学中的作用。最后，讨论了高尔基体在阿尔茨海默病发病机制中的作用。了解高尔基体功能障碍对阿尔茨海默病的影响及其病理生理基础，将对我们开发更有效的阿尔茨海默病治疗方法的能力产生重大影响。
