Craanen M E, Dekker W, Blok P, Ferwerda J, Tytgat G N
Department of Internal Medicine, St Elisabeth's of Groote Gasthuis, Haarlem, The Netherlands.
Gut. 1992 Jan;33(1):16-20. doi: 10.1136/gut.33.1.16.
To study the relationship between intestinal metaplasia and Helicobacter pylori infection, 2274 gastroscopic antral biopsies taken from 533 patients were examined. Overall, intestinal metaplasia was found in 135 patients (25.3%) and H pylori in 289 patients (54.2%). The prevalence of intestinal metaplasia and H pylori was age related, being more common in patients greater than or equal to 50 years compared with patients less than 50 years (intestinal metaplasia, p less than 0.001 and H pylori, p less than 0.05). Intestinal metaplasia was found more often in H pylori positive patients compared with H pylori negative patients (33.9% v 15.2%, p less than 0.001). The mean age of intestinal metaplasia positive patients who were also H pylori positive was 64 (13.3) years, whereas the mean age of intestinal metaplasia positive patients who were H pylori negative was 72 (14.7) years (p less than 0.005). The extent of intestinal metaplasia was not statistically different in the latter two groups. Although our data do not prove a causal relationship between H pylori infection and the histogenesis of intestinal metaplasia it is suggested that H pylori infection is an important factor in the development of intestinal metaplasia, which is generally recognised as a precursor lesion of intestinal type gastric carcinoma.
为研究肠化生与幽门螺杆菌感染之间的关系，对取自533例患者的2274份胃镜下胃窦活检标本进行了检查。总体而言，135例患者（25.3%）发现有肠化生，289例患者（54.2%）发现有幽门螺杆菌。肠化生和幽门螺杆菌的患病率与年龄相关，与50岁以下患者相比，50岁及以上患者更为常见（肠化生，p<0.001；幽门螺杆菌，p<0.05）。与幽门螺杆菌阴性患者相比，幽门螺杆菌阳性患者中肠化生更为常见（33.9%对15.2%，p<0.001）。幽门螺杆菌阳性的肠化生阳性患者的平均年龄为64（13.3）岁，而幽门螺杆菌阴性的肠化生阳性患者的平均年龄为72（14.7）岁（p<0.005）。后两组肠化生的程度无统计学差异。虽然我们的数据不能证明幽门螺杆菌感染与肠化生的组织发生之间存在因果关系，但提示幽门螺杆菌感染是肠化生发生发展的一个重要因素，而肠化生通常被认为是肠型胃癌的前驱病变。
