幽门螺杆菌根除对术后早期胃癌预后的影响：一项多中心研究。
The effect of Helicobacter pylori eradication on prognosis of postoperative early gastric cancer: a multicenter study.
作者信息
Wang Liang, Wang Jinfeng, Li Sha, Bai Fei, Xie Hailong, Shan Hanguo, Liu Zhuo, Ma Tiexiang, Tang Xiayu, Tang Haibing, Qin Ang, Lei Sanlin, Zuo Chaohui
机构信息
Graduates School, University of South China, 28 Zhengxiang Road, Hengyang, Hunan Province, 421001, People's Republic of China.
Department of Gastroduodenal and Pancreatic Surgery, Translational Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, Hunan Cancer Hospital (Hunan Cancer Institute) & the Affiliated Cancer Hospital of Xiangya School of Medicine, Hunan Province Key Laboratory of Virology (Tumor Immunity), Central South University, 283 Tongzipo Road, Changsha, Hunan Province, 410013, People's Republic of China.
出版信息
World J Surg Oncol. 2021 Sep 21;19(1):285. doi: 10.1186/s12957-021-02343-x.
OBJECTIVE
To investigate the effect of Helicobacter pylori (H. pylori) eradication on the prognosis of postoperative early gastric cancer (EGC).
METHODS
This is a retrospective study based on data from 6 hospitals. We identified 429 patients with EGC who underwent curative gastrectomy from January 2010 to December 2016. All of the patients were tested for H. pylori. Patients were divided into two groups, the successful H. pylori eradication group (group A, 268 patients) and the non-H. pylori eradication group (group B, 161 patients), for calculating the disease-free survival (DFS) and overall survival (OS) of each group.
RESULT
Positive node metastasis (hazard ratio (HR), 3.13; 95% confidence interval (CI), 1.84-5.32; P < 0.001), undifferentiated type (HR, 2.54; 95% CI, 1.51-4.28; P < 0.001), and non-H. pylori eradication (HR, 1.73; 95% CI, 1.08-2.77; P = 0.023) were statistically significantly independent risk factors of recurrence. Patient's age ≥60 years old (HR, 3.32; 95% CI, 2.00-5.53; P < 0.001), positive node metastasis (HR, 3.71; 95% CI, 2.25-6.12; P < 0.001), undifferentiated type (HR, 3.06; 95% CI, 1.79-5.23; P < 0.001), and non-H. pylori eradication (HR, 1.83; 95% CI, 1.11-3.02; P = 0.018) were statistically significantly independent risk factors of overall survival.
CONCLUSION
H. pylori eradication treatment could prevent the recurrence of postoperative EGC to prolong the overall survival of patients with EGC.
目的
探讨幽门螺杆菌（H. pylori）根除对早期胃癌（EGC）术后预后的影响。
方法
这是一项基于6家医院数据的回顾性研究。我们纳入了2010年1月至2016年12月期间接受根治性胃切除术的429例EGC患者。所有患者均接受了H. pylori检测。患者被分为两组，即幽门螺杆菌成功根除组（A组，268例患者）和未根除幽门螺杆菌组（B组，161例患者），以计算每组的无病生存期（DFS）和总生存期（OS）。
结果
阳性淋巴结转移（风险比（HR），3.13；95%置信区间（CI），1.84 - 5.32；P < 0.001）、未分化型（HR，2.54；95% CI，1.51 - 4.28；P < 0.001）和未根除幽门螺杆菌（HR，1.73；95% CI，1.08 - 2.77；P = 0.023）是复发的统计学显著独立危险因素。患者年龄≥60岁（HR，3.32；95% CI，2.00 - 5.53；P < 0.001）、阳性淋巴结转移（HR，3.71；95% CI，2.25 - 6.12；P < 0.001）、未分化型（HR，3.06；95% CI，1.79 - 5.23；P < 0.001）和未根除幽门螺杆菌（HR，1.83；95% CI，1.11 - 3.02；P = 0.0 l8）是总生存期的统计学显著独立危险因素。
结论
根除幽门螺杆菌治疗可预防EGC术后复发，延长EGC患者的总生存期。
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