Carby Martin, Jones Andrew, Burke Margaret, Hall Anne, Banner Nicholas
Department of Transplantation, Harefield Hospital, Harefield, Middlesex, United Kingdom.
J Heart Lung Transplant. 2007 Apr;26(4):399-402. doi: 10.1016/j.healun.2007.01.007.
Disseminated varicella-zoster virus infection after organ transplantation in adults is a rare but serious event causing significant morbidity and mortality. We describe our 10-year experience of 13 cases in a single center, including risk factors for infection, lack of protection from pre-existing anti-varicella-zoster virus antibodies, and unusual modes of presentation, including disseminated intravascular coagulation. We also report our preliminary observation of resolution of infection without sequelae in 4 patients with severe disseminated varicella-zoster virus infection who were treated with the combination of intravenous acyclovir and polyspecific intravenous immunoglobulin.
成人器官移植后播散性水痘-带状疱疹病毒感染是一种罕见但严重的事件，可导致显著的发病率和死亡率。我们描述了在单一中心10年间13例患者的经验，包括感染的危险因素、缺乏来自既往抗水痘-带状疱疹病毒抗体的保护以及不寻常的表现形式，包括弥散性血管内凝血。我们还报告了对4例严重播散性水痘-带状疱疹病毒感染患者的初步观察结果，这些患者接受静脉注射阿昔洛韦和多特异性静脉注射免疫球蛋白联合治疗后感染得到缓解且无后遗症。
