Kumar Velayudhan Mohan, Vetrivelan Ramalingam, Mallick Hruda Nanda
Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695011, India.
Neurochem Int. 2007 May;50(6):783-90. doi: 10.1016/j.neuint.2007.02.004. Epub 2007 Feb 27.
Several studies have shown the importance of the medial preoptic area in the regulation of sleep-wakefulness and of body temperature. The medial preoptic area has a rich noradrenergic innervation, coming mostly from the lateral tegmental noradrenergic system. The accumulating evidences show that the noradrenergic afferents to the medial preoptic area are involved in the induction of sleep. This hypnogenic mechanism operates through the postsynaptic alpha1 and alpha2-adrenergic receptors. Noradrenergic afferents are also involved in the thermoregulatory mechanisms, and the activation of these fibers brings about a fall in body temperature. Though the body temperature changes are brought about by the same receptor subtypes as those involved in hypnogenesis, observations suggest the possibility of separate sets of noradrenergic afferents in the medial preoptic area for sleep regulation and thermoregulation. In this review, we present the compelling evidences, which showed that the noradrenergic afferents of the medial preoptic area bring about a fall in body temperature and other thermoregulatory behavioral alterations associated with sleep.
多项研究表明，内侧视前区在调节睡眠-觉醒和体温方面具有重要作用。内侧视前区有丰富的去甲肾上腺素能神经支配，主要来自外侧被盖去甲肾上腺素能系统。越来越多的证据表明，内侧视前区的去甲肾上腺素能传入神经参与睡眠诱导。这种促眠机制通过突触后α1和α2肾上腺素能受体发挥作用。去甲肾上腺素能传入神经也参与体温调节机制，这些纤维的激活会导致体温下降。尽管体温变化是由与促眠作用相同的受体亚型引起的，但观察结果表明，内侧视前区可能存在不同的去甲肾上腺素能传入神经组，分别用于睡眠调节和体温调节。在这篇综述中，我们展示了令人信服的证据，表明内侧视前区的去甲肾上腺素能传入神经会导致体温下降以及与睡眠相关的其他体温调节行为改变。
