Kitaguchi Hiroshi, Ihara Masafumi, Saiki Hidemoto, Takahashi Ryosuke, Tomimoto Hidekazu
Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.
Neurosci Lett. 2007 May 1;417(2):128-31. doi: 10.1016/j.neulet.2007.02.021. Epub 2007 Feb 11.
Morphological abnormalities of the cortical microvessels have been reported in Alzheimer's disease (AD), but not in Binswanger's disease (BD), a form of vascular dementia. Therefore, we compared the capillary beds in AD and BD brains, using a modified Gallyas silver impregnation method and immunohistochemistry for beta amyloid. Eight autopsied brains with AD and seven with BD were compared with six control brains. The cortical microvessels in AD were frequently narrowed, and torn off, especially in close proximity to the senile plaques. The capillary densities in AD were significantly decreased as compared with the control brains. In contrast, there were no significant changes in the capillary densities and their morphologies in BD brains. Immunohistochemistry for beta amyloid revealed numerous deposits in the vascular wall and perivascular neuropil exclusively in AD brains. Cortical microvascular changes in AD and their absence in BD may indicate a role of beta amyloid for the microvessel pathology in AD.
在阿尔茨海默病（AD）中已报道有皮质微血管的形态学异常，但在血管性痴呆的一种形式——宾斯旺格病（BD）中未发现。因此，我们使用改良的加利亚斯银浸染法和β淀粉样蛋白免疫组织化学方法，比较了AD和BD患者大脑中的毛细血管床。将8例AD尸检大脑和7例BD尸检大脑与6例对照大脑进行了比较。AD患者的皮质微血管经常变窄并断裂，尤其是在老年斑附近。与对照大脑相比，AD患者的毛细血管密度显著降低。相比之下，BD患者大脑中的毛细血管密度及其形态没有显著变化。β淀粉样蛋白免疫组织化学显示，仅在AD患者大脑的血管壁和血管周围神经纤维网中有大量沉积物。AD患者皮质微血管的变化以及BD患者中未出现这种变化，可能表明β淀粉样蛋白在AD患者微血管病变中起作用。
