Grunwald J E, Riva C E, Baine J, Brucker A J
Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, Philadelphia 19104.
Invest Ophthalmol Vis Sci. 1992 Feb;33(2):356-63.
Total retinal volumetric blood flow rate was measured in 12 normal subjects and 18 poorly controlled diabetic patients with background diabetic retinopathy. Maximum or center-line erythrocyte velocity (Vmax) was assessed by bidirectional laser Doppler velocimetry in four to five major retinal veins of one eye of each subject. Venous diameter (D) was measured from monochromatic fundus photographs. Total venous cross-section and measured total retinal volumetric blood flow in the diabetic patients were significantly larger than normal (P = 0.001 and P = 0.02, respectively). A positive linear correlation was found between Vmax and D in normal and diabetic eyes. Volumetric blood flow rate, Q, varied with D at a power of 2.87 in normal eyes. Total volumetric blood flow correlated with total venous cross-section. It was found that Q in the temporal retina was significantly larger than in the nasal retina in normal subjects (P = 0.0008) and diabetic patients (P = 0.0002). A significant difference in Q was observed between the superior and inferior retina in diabetic patients (P = 0.03) but not in normal subjects. The retinal vascular regulatory response to 100% oxygen breathing was reduced (P = 0.019) in diabetic patients and correlated with the level of background diabetic retinopathy. A close estimate of total volumetric blood flow may be obtained from blood flow measurement in one major retinal vein and the determination of total venous cross-section. This may be important for clinical studies in which measurements of all individual retinal veins may not be feasible.
在12名正常受试者和18名患有背景性糖尿病视网膜病变且血糖控制不佳的糖尿病患者中测量了视网膜总体积血流率。通过双向激光多普勒测速法评估了每个受试者一只眼睛的四到五条主要视网膜静脉中的最大或中心线红细胞速度（Vmax）。从单色眼底照片测量静脉直径（D）。糖尿病患者的总静脉横截面积和测量的视网膜总体积血流均显著大于正常受试者（分别为P = 0.001和P = 0.02）。在正常和糖尿病眼中，Vmax与D之间发现正线性相关。在正常眼中，体积血流率Q随D的2.87次方变化。总体积血流与总静脉横截面积相关。发现在正常受试者（P = 0.0008）和糖尿病患者（P = 0.0002）中，颞侧视网膜的Q显著大于鼻侧视网膜。在糖尿病患者中，上、下视网膜之间的Q存在显著差异（P = 0.03），但在正常受试者中未观察到。糖尿病患者对100%氧气呼吸的视网膜血管调节反应降低（P = 0.019），且与背景性糖尿病视网膜病变的程度相关。通过测量一条主要视网膜静脉中的血流并确定总静脉横截面积，可以获得总体积血流的近似估计值。这对于无法测量所有单个视网膜静脉的临床研究可能很重要。
