γ干扰素在炎症和自身免疫性疾病中的阴阳相互作用。
Yin and yang interplay of IFN-gamma in inflammation and autoimmune disease.
作者信息
Zhang Jingwu
机构信息
Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine, and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
出版信息
J Clin Invest. 2007 Apr;117(4):871-3. doi: 10.1172/JCI31860.
IFN-gamma has long been recognized as a signature proinflammatory cytokine that plays a central role in inflammation and autoimmune disease. There is now emerging evidence indicating that IFN-gamma possesses unexpected properties as a master regulator of immune responses and inflammation. In this issue of the JCI, Guillonneau et al. show that indefinite allograft survival induced by CD40Ig treatment is mediated by CD8(+)CD45RC(low) T cells through the production of IFN-gamma (see the related article beginning on page 1096), supporting the emerging view that IFN-gamma is critical in the self-regulation of inflammation. These contradictory roles of IFN-gamma, perhaps best understood by the principle of yin and yang, represent one of nature's paradoxes, whereby the same cytokine functions as an inducer as well as a regulator for inflammation. Understanding this complex process of IFN-gamma signaling is essential, as it has therapeutic implications.
长期以来，γ干扰素一直被认为是一种标志性的促炎细胞因子，在炎症和自身免疫性疾病中起核心作用。现在有新出现的证据表明，γ干扰素作为免疫反应和炎症的主要调节因子具有意想不到的特性。在本期《临床研究杂志》中，吉洛诺等人表明，CD40Ig治疗诱导的同种异体移植物无限期存活是由CD8(+)CD45RC(低)T细胞通过产生γ干扰素介导的（见第1096页开始的相关文章），这支持了γ干扰素在炎症自我调节中至关重要这一新兴观点。γ干扰素的这些矛盾作用，或许用阴阳学说来理解最为恰当，代表了自然界的悖论之一，即同一种细胞因子既作为炎症的诱导剂又作为调节剂发挥作用。理解γ干扰素信号传导的这一复杂过程至关重要，因为它具有治疗意义。
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