Waddell S C, Davison J S, Befus A D, Mathison R D
Department of Medical Physiology, Faculty of Medicine, University of Calgary, Alberta, Canada.
J Manipulative Physiol Ther. 1992 Jan;15(1):10-5.
This study tests the hypothesis that spinal nerves projecting down the cervical sympathetic trunk contribute to the regulation of systemic immune responses. Decentralization or ablation (ganglionectomy) of the superior cervical ganglia (SCG), which receive innervation from spinal segments C8-T8, were found to reduce the pulmonary inflammatory response consequent to induction of anaphylaxis in rats sensitized to the nematode Nippostrongylus brasiliensis. Furthermore, the hypotensive responses to IV endotoxin were attenuated in sensitized rats by these operations, whereas decentralization without ganglionectomy protected against endotoxic shock in normal (unsensitized) rats. These results suggest that systemic inflammatory events are regulated by the cervical sympathetic nervous system at a level superior to the superior cervical ganglia. Further studies are warranted to investigate the role of the cervical and thoracic sympathetic nerves in the regulation of systemic immunological function.
沿颈交感干下行的脊神经有助于调节全身免疫反应。接受来自C8 - T8脊髓节段神经支配的颈上神经节（SCG）去传入或切除（神经节切除术）后，发现可减轻对巴西日圆线虫致敏的大鼠在诱发过敏反应后产生的肺部炎症反应。此外，这些手术使致敏大鼠对内毒素静脉注射的降压反应减弱，而未进行神经节切除术的去传入则可保护正常（未致敏）大鼠免受内毒素休克。这些结果表明，全身炎症事件在高于颈上神经节的水平受到颈交感神经系统的调节。有必要进一步研究颈交感神经和胸交感神经在调节全身免疫功能中的作用。
