Mathison R, Davison J S, De Sanctis G, Green F, Befus D A
Department of Medical Physiology, Faculty of Medicine, University of Calgary, Alberta, Canada.
Proc Soc Exp Biol Med. 1992 Sep;200(4):542-7. doi: 10.3181/00379727-200-43468.
Bilateral decentralization of the superior cervical ganglia protects against pulmonary inflammation when measured 8 hr after induction of anaphylaxis in rats sensitized to the nematode, Nippostrongylus brasiliensis. Since anaphylactic shock produces immediate perturbations to the cardiovascular and respiratory systems, we examined whether bilateral decentralization of the superior cervical ganglia modified the responses of these two systems during the first 4 hr of the anaphylactic response. With the exception of the bronchioles, decentralization did not protect against anaphylaxis-associated increases in extravasation of albumin, and the small changes in respiratory function induced by anaphylaxis were unaffected by the denervation. Decentralization did not alter anaphylaxis-induced reductions in blood flow to the gastrointestinal tract; however, blood flow to the kidneys and spleen of decentralized rats was restored more rapidly to normal values. These results suggest that the protective effect of decentralization on the late phase pulmonary inflammation of anaphylaxis is unrelated to early changes in respiratory mechanics, although the protection may be facilitated by the more rapid re-establishment of normal cardiovascular homeostasis.
在对巴西日圆线虫致敏的大鼠中，诱导过敏反应8小时后进行测量，发现双侧颈上神经节去神经支配可预防肺部炎症。由于过敏性休克会立即对心血管和呼吸系统产生干扰，我们研究了双侧颈上神经节去神经支配是否会在过敏反应的最初4小时内改变这两个系统的反应。除细支气管外，去神经支配并不能预防与过敏反应相关的白蛋白外渗增加，过敏反应引起的呼吸功能微小变化也不受去神经支配的影响。去神经支配并未改变过敏反应引起的胃肠道血流减少；然而，去神经支配大鼠的肾脏和脾脏血流恢复到正常水平的速度更快。这些结果表明，去神经支配对过敏反应后期肺部炎症的保护作用与呼吸力学的早期变化无关，尽管正常心血管稳态的更快重建可能有助于这种保护作用。
