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粗糙脉孢菌NAD特异性谷氨酸脱氢酶的部分氨基酸序列

Partial amino-acid sequence of NAD-specific glutamate dehydrogenase of Neurospora crassa.

作者信息

Austen B M, Nyc J F, Degani Y, Smith E L

出版信息

Proc Natl Acad Sci U S A. 1975 Dec;72(12):4891-4. doi: 10.1073/pnas.72.12.4891.

DOI:10.1073/pnas.72.12.4891
PMID:174080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388838/
Abstract

Parts of the primary structure of the NAD-specific glutamate dehydrogenase [L-glutamate:NAD oxidoreductase (deaminating), EC 1.4.1.2] from Neurospora crassa are presented. Segments of the sequence representing 886 unique amino-acid residues have been determined; the largest contains 267 residues. There are only short regions of possible homology between this enzyme and the glutamate dehydrogenases of bovine liver or the NADP-specific enzyme of Neurospora. The large size of the subunit (116,000 molecular weight) of the NAD-specific glutamate dehydrogenase is unusual when compared to other known dehydrogenases.

摘要

本文展示了粗糙脉孢菌中NAD特异性谷氨酸脱氢酶[L-谷氨酸：NAD氧化还原酶（脱氨基），EC 1.4.1.2]一级结构的部分内容。已确定代表886个独特氨基酸残基的序列片段；最大的片段包含267个残基。该酶与牛肝谷氨酸脱氢酶或粗糙脉孢菌的NADP特异性酶之间仅存在可能的短同源区域。与其他已知脱氢酶相比，NAD特异性谷氨酸脱氢酶的亚基（分子量116,000）尺寸较大，这很不寻常。

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本文引用的文献

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Effect of glutamic acid on the formation of two glutamic acid dehydrogenases of Neurospora.谷氨酸对粗糙脉孢菌两种谷氨酸脱氢酶形成的影响。
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An examination of conditions for the cleavage of polypeptide chains with cyanogen bromide: application to catalase.溴化氰裂解多肽链的条件研究：应用于过氧化氢酶
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J Biol Chem. 1973 Mar 10;248(5):1672-83.
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Carboxypeptidase from yeast. Large scale preparation and the application to COOH-terminal analysis of peptides and proteins.酵母羧肽酶。大规模制备及其在肽和蛋白质羧基末端分析中的应用。
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Staphylococcal protease: a proteolytic enzyme specific for glutamoyl bonds.葡萄球菌蛋白酶：一种对谷氨酰键具有特异性的蛋白水解酶。
Proc Natl Acad Sci U S A. 1972 Dec;69(12):3506-9. doi: 10.1073/pnas.69.12.3506.
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Nicotinamide adenine dinucleotide-specific glutamate dehydrogenase of Neurospora. III. Isolation and sequences of peptides containing selectively labeled lysine and cysteine residues.粗糙脉孢菌的烟酰胺腺嘌呤二核苷酸特异性谷氨酸脱氢酶。III. 含有选择性标记赖氨酸和半胱氨酸残基的肽段的分离与序列分析
J Biol Chem. 1974 Dec 25;249(24):7936-41.

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