Kirbas G, Abakay A, Topcu F, Kaplan A, Unlü M, Peker Y
Sleep Centre, Department of Chest Diseases, Medical Faculty, Dicle University, Diyarbakir, Turkey.
J Int Med Res. 2007 Jan-Feb;35(1):38-45. doi: 10.1177/147323000703500103.
This study evaluated the impact of obstructive sleep apnoea (OSA) and smoking on total serum testosterone levels in 96 men (mean age 43.3 years; range 25 - 60 years) attending a sleep clinic. Fifty-five men (57.3%) had OSA, defined as an apnoea-hypopnoea index of > or = 15 events/h, recorded during overnight polysomnography, and 42 (43.8%) were current smokers. Mean serum total testosterone levels were significantly lower in OSA subjects (3.4 ng/ml) than in non-OSA subjects (3.9 ng/ml), whereas no significant difference was observed between current smokers and nonsmokers. In a multiple linear regression analysis, serum testosterone was negatively correlated with body mass index and the apnoea-hypopnoea index, but not with age and pack-years of smoking. Our results support previous observations regarding testosterone levels in men with OSA, but, contrary to some earlier reports, there was no positive relationship between smoking and total testosterone in the present cohort.
本研究评估了阻塞性睡眠呼吸暂停（OSA）和吸烟对96名前往睡眠诊所就诊的男性（平均年龄43.3岁；范围25 - 60岁）血清总睾酮水平的影响。55名男性（57.3%）患有OSA，定义为夜间多导睡眠图记录的呼吸暂停低通气指数≥15次/小时，42名（43.8%）为当前吸烟者。OSA患者的平均血清总睾酮水平（3.4 ng/ml）显著低于非OSA患者（3.9 ng/ml），而当前吸烟者与非吸烟者之间未观察到显著差异。在多元线性回归分析中，血清睾酮与体重指数和呼吸暂停低通气指数呈负相关，但与年龄和吸烟包年数无关。我们的结果支持了先前关于OSA男性睾酮水平的观察结果，但与一些早期报告相反，在本队列中吸烟与总睾酮之间没有正相关关系。
