Wykes Michelle, Good Michael F
The Queensland Institute of Medical Research, The Bancroft Centre, Brisbane, Qld, Australia.
Int J Parasitol. 2007 Jun;37(7):705-12. doi: 10.1016/j.ijpara.2007.02.007. Epub 2007 Feb 28.
Malaria causes morbidity in 300-500 million people each year and claims 2-3 millions lives annually, mostly children in sub-Saharan Africa. In 1983, the cloning of malaria antigens offered great promise for developing a viable subunit vaccine. However, an efficacious human vaccine is still not available. Immunological studies on how the host's immune system interacts with the parasite and studies on the pathogenic aspect of Plasmodium have found that several factors can impede protection by current vaccines. These findings suggest a novel approach needs to be considered.
疟疾每年致使3亿至5亿人发病，每年造成200万至300万人死亡，其中大多数是撒哈拉以南非洲的儿童。1983年，疟疾抗原的克隆为开发一种可行的亚单位疫苗带来了巨大希望。然而，目前仍没有有效的人类疫苗。关于宿主免疫系统如何与寄生虫相互作用的免疫学研究以及对疟原虫致病方面的研究发现，有几个因素会阻碍现有疫苗的保护作用。这些发现表明需要考虑一种新的方法。
