盘基网柄菌中细胞性黏菌趋化反应的信号输入。
Signal input for a chemotactic response in the cellular slime mold Dictyostelium discoideum.
作者信息
Mato J M, Losada A, Nanjundiah V, Konijn T M
出版信息
Proc Natl Acad Sci U S A. 1975 Dec;72(12):4991-3. doi: 10.1073/pnas.72.12.4991.
Abstract
Drops with different concentrations of 3':5'-cyclic AMP were deposited at various distances from small populations of Dictyostelium discoideum amoebae, and the distances over which 50% of the amoebae drops reacted positively were determined. The linear regression analysis of a bouble logarithmic plot of distance against concentration gives a straight line with a slope of 1/4.25, which value suggests that the amoebae respond to a spatial gradient of cyclic AMP concentration. The threshold value for the signal is 3.6 X 10(-9) M/mm with a sensitivity of measurement of about 1%. These findings are discussed in relation to our present knowledge of cyclic AMP receptors.
摘要
将不同浓度的3':5'-环磷酸腺苷（3':5'-cyclic AMP）液滴，放置在离少量盘基网柄菌（Dictyostelium discoideum）变形虫不同距离处，测定50%的变形虫液滴产生阳性反应的距离。以距离对浓度作双对数图进行线性回归分析，得到一条斜率为1/4.25的直线，该值表明变形虫对环磷酸腺苷浓度的空间梯度有反应。信号的阈值为3.6×10⁻⁹摩尔/毫米，测量灵敏度约为1%。结合我们目前对环磷酸腺苷受体的了解，对这些发现进行了讨论。
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