Alaei Hojjatallah, Hosseini Mahmood
Department of Physiology, School of medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Physiology, School of medicine, Esfahan University of Medical Sciences, Esfahan, Iran.
Pathophysiology. 2007 May;14(1):55-60. doi: 10.1016/j.pathophys.2007.01.002. Epub 2007 Apr 3.
Angiotensin II and angiotensin converting enzyme (ACE) inhibitors have analgesic, anticonvulsant and antidepressive effects and in some cases they can antagonize morphine. In the present study effects of angiotensin II and ACE inhibitor captopril administered intracerobroventricularily (icv) on conditioned place preference induced by morphine as well as on morphine withdrawal signs has been evaluated in rats. Icv canullas were implanted in anesthetized male rats. Rats were allowed to recover from the surgery and conditioned place preference was induced by morphine, and the time spent in morphine compartment was compared in saline, morphine, captopril and Ang II groups. Morphine withdrawal signs were compared in three other groups of rats: morphine alone, captopril+morphine and Ang II+morphine 4 days after morphine injections (three times in each day) with naloxone injection on 4th day. Results with rats conditioned place preference induced by morphine showed that icv captopril decreased significantly the time in morphine compartment (P<0.01) while Ang II had no effect. In morphine dependent rats captopril decreased some withdrawal signs after naloxone precipitation (P<0.05 and P<0.01). Ang II administration augmented some of withdrawal signs than in the morphine group (P<0.01 and P<0.001). In conclusion captopril reduced conditioned place preference induced by morphine and some withdrawal signs in morphine dependent rats.
血管紧张素 II 和血管紧张素转换酶（ACE）抑制剂具有镇痛、抗惊厥和抗抑郁作用，在某些情况下它们可以拮抗吗啡。在本研究中，已评估了向大鼠脑室内（icv）注射血管紧张素 II 和 ACE 抑制剂卡托普利对吗啡诱导的条件性位置偏爱以及吗啡戒断症状的影响。将 icv 套管植入麻醉的雄性大鼠体内。大鼠从手术中恢复后，用吗啡诱导条件性位置偏爱，并比较生理盐水、吗啡、卡托普利和血管紧张素 II 组在吗啡区停留的时间。在另外三组大鼠中比较吗啡戒断症状：在每天注射三次吗啡（共注射四天）后第四天注射纳洛酮，这三组分别为单独注射吗啡组、卡托普利 + 吗啡组和血管紧张素 II + 吗啡组。吗啡诱导条件性位置偏爱的大鼠实验结果表明，icv注射卡托普利显著减少了在吗啡区停留的时间（P<0.01），而血管紧张素 II 没有影响。在吗啡依赖的大鼠中，卡托普利在纳洛酮诱发戒断后减轻了一些戒断症状（P<0.05 和 P<0.01）。与吗啡组相比，注射血管紧张素 II 增强了一些戒断症状（P<0.01 和 P<0.001）。总之，卡托普利减少了吗啡诱导的条件性位置偏爱以及吗啡依赖大鼠的一些戒断症状。
