Hosseini Mahmoud, Sharifi Mohammad Reza, Alaei Hojatallah, Shafei Mohammad Naser, Karimooy Habib Allah Nemati
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Indian J Exp Biol. 2007 Sep;45(9):770-7.
The effects of captopril and Ang II on morphine-induced conditioned place preference (CPP) and morphine self-administration in male Wistar rat were investigated. In CPP experiment, injection of captopril before test significantly decreased the difference of the time spent in compartment A between pre- and post-conditioning compared to morphine group. In self- administration experiment number of active lever pressing was significantly greater than passive in morphine group. In captopril group number of active lever pressing was significantly lower than morphine group however, there was not significant difference between active and passive lever pressed number. The results showed that captopril significantly decreased morphine-induced conditional place preference and morphine self-administration but the effect of Ang II was not significant. It can be concluded that RAS may have a role in rewarding properties of morphine.
研究了卡托普利和血管紧张素II（Ang II）对雄性Wistar大鼠吗啡诱导的条件性位置偏爱（CPP）和吗啡自我给药的影响。在CPP实验中，与吗啡组相比，测试前注射卡托普利显著降低了条件化前后在A区停留时间的差异。在自我给药实验中，吗啡组主动压杆次数显著多于被动压杆次数。在卡托普利组，主动压杆次数显著低于吗啡组，然而，主动和被动压杆次数之间没有显著差异。结果表明，卡托普利显著降低了吗啡诱导的条件性位置偏爱和吗啡自我给药，但Ang II的作用不显著。可以得出结论，肾素-血管紧张素系统（RAS）可能在吗啡的奖赏特性中起作用。
