Adjuvant effects of crystal proteins from a Mexican strain of Bacillus thuringiensis on the mouse humoral response.

作者信息

Román Calderón Máximo E, Alcocer González Juan M, Franco Molina Moisés A, Tamez Guerra Reyes S, Rodríguez Padilla Cristina

机构信息

Laboratorio de Inmunología y Virología, Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Apartado Postal 46 "F", C.P. 66450, Nuevo León, Mexico.

出版信息

Biologicals. 2007 Oct;35(4):271-6. doi: 10.1016/j.biologicals.2007.01.006. Epub 2007 Apr 3.

DOI:10.1016/j.biologicals.2007.01.006

PMID:17408965

Abstract

In this study, we determined the adjuvant effects of the crystal (Cry) proteins, p130, p98, and p64-62, on the immune response of mice to both sheep red blood cells (SRBC) and ovalbumin (OVA). The administration of p130, p98, and p64-62 Cry proteins to Balb/c mice induced a significant (p<0.01) increase in the production of anti-SRBC antibody-secreting cells (ASC). The p64-62 Cry proteins demonstrated the best ability to induce the production of IgA and IgG antibodies to SRBC (p<0.05), and IgM, IgA, and IgG antibodies to OVA (p<0.05). Additionally, Cry proteins did not produce any side effects associated with their administration to Balb/c mice. We suggest the potential use of the p64-62 Cry proteins as adjuvants for the administration of heterologous antigens.

摘要