通过测量和检验哈迪-温伯格平衡及连锁不平衡进行生存数量性状基因座精细定位。
Survival quantitative trait locus fine mapping by measuring and testing for Hardy-Weinberg and linkage disequilibrium.
作者信息
Casellas J
机构信息
Grup de Recerca en Remugants, Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
出版信息
Genetics. 2007 May;176(1):721-4. doi: 10.1534/genetics.106.067264. Epub 2007 Apr 3.
Abstract
I show that fine-scale localization of a survival-related locus can be accomplished on the basis of deviations from Hardy-Weinberg equilibrium and linkage disequilibrium at closely linked marker loci. The method is based on chi(2)-tests and they can be performed for age-specific samples of alive (or dead) individuals, as for combined samples of alive and dead individuals.
摘要
我证明了与生存相关的基因座的精细定位可以基于紧密连锁的标记基因座上偏离哈迪-温伯格平衡和连锁不平衡来完成。该方法基于卡方检验，可针对存活（或死亡）个体的年龄特异性样本进行，也可针对存活和死亡个体的组合样本进行。
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