Bengtsson B O, Thomson G
Tissue Antigens. 1981 Nov;18(5):356-63. doi: 10.1111/j.1399-0039.1981.tb01404.x.
The strength of the population association between an antigen and a disease can be estimated not only by the relative risk value, but also by what variously has been called the population attributable risk and the etiologic fraction. This alternative measure has certain advantages if the association is due to linkage disequilibrium between the antigen allele and a "disease" allele at a closely linked "disease susceptibility" locus. In particular, it can then be used to determine which of many antigens associated with the same disease has the strongest association from a genetical point of view.
抗原与疾病之间的群体关联强度不仅可以通过相对风险值来估计，还可以通过各种被称为群体归因风险和病因分数的指标来估计。如果这种关联是由于抗原等位基因与紧密连锁的“疾病易感性”位点上的“疾病”等位基因之间的连锁不平衡所致，那么这种替代指标具有一定优势。特别是，从遗传学角度来看，它可用于确定与同一种疾病相关的多种抗原中哪一种具有最强的关联性。
