Ogawa Yuko, Oku Hisae, Iwaoka Emiko, Iinuma Munekazu, Ishiguro Kyoko
School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
Chem Pharm Bull (Tokyo). 2007 Apr;55(4):675-8. doi: 10.1248/cpb.55.675.
Allergy-preventive activity was demonstrated for an extract of resins from Xanthorrhoea hastilis R. BR. in a search for allergy-preventive substances from natural sources. By bioassay-directed fractionation of this plant extract, a new flavanone, 3',5'-dihydroxy-7,4'-dimethoxyflavanone (1), and two new chalcones, 3,5,2'-trihydroxy-4,4'-dimethoxychalcone (2) and 5,2'-dihydroxy-3,4,4'-trimethoxychalcone (3), were isolated together with five known compounds, 5'-hydroxy-7,3',4'-trimethoxyflavanone (4), 3'-hydroxy-7,4'-dimethoxyflavanone (5), liquiritigenin 7-methyl ether (6), 4,2'-dihydroxy-4'-methoxychalcone (7) and sakuranetin (8). The structures of 1, 2 and 3 were elucidated by spectroscopic methods. All of these compounds showed allergy-preventive effects.
为了从天然来源寻找预防过敏的物质，对澳洲刺叶树（Xanthorrhoea hastilis R. BR.）树脂提取物的预防过敏活性进行了研究。通过对该植物提取物进行生物活性导向的分离，得到了一种新的黄烷酮3',5'-二羟基-7,4'-二甲氧基黄烷酮（1）、两种新的查耳酮3,5,2'-三羟基-4,4'-二甲氧基查耳酮（2）和5,2'-二羟基-3,4,4'-三甲氧基查耳酮（3），同时还分离出了五种已知化合物5'-羟基-7,3',4'-三甲氧基黄烷酮（4）、3'-羟基-7,4'-二甲氧基黄烷酮（5）、甘草素7-甲醚（6）、4,2'-二羟基-4'-甲氧基查耳酮（7）和樱花素（8）。通过光谱方法确定了化合物1、2和3的结构。所有这些化合物均表现出预防过敏的作用。
