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佩吉特病中的脊柱。

The spine in Paget's disease.

作者信息

Dell'Atti C, Cassar-Pullicino V N, Lalam R K, Tins B J, Tyrrell P N M

机构信息

Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic and District Hospital, Oswestry, SY10 7AG, UK.

出版信息

Skeletal Radiol. 2007 Jul;36(7):609-26. doi: 10.1007/s00256-006-0270-6. Epub 2007 Apr 5.

DOI:10.1007/s00256-006-0270-6
PMID:17410356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1934928/
Abstract

Paget's disease (PD) is a chronic metabolically active bone disease, characterized by a disturbance in bone modelling and remodelling due to an increase in osteoblastic and osteoclastic activity. The vertebra is the second most commonly affected site. This article reviews the various spinal pathomechanisms and osseous dynamics involved in producing the varied imaging appearances and their clinical relevance. Advanced imaging of osseous, articular and bone marrow manifestations of PD in all the vertebral components are presented. Pagetic changes often result in clinical symptoms including back pain, spinal stenosis and neural dysfunction. Various pathological complications due to PD involvement result in these clinical symptoms. Recognition of the imaging manifestations of spinal PD and the potential complications that cause the clinical symptoms enables accurate assessment of patients prior to appropriate management.

摘要

佩吉特病（PD）是一种慢性代谢活跃性骨病，其特征是由于成骨细胞和破骨细胞活性增加导致骨塑形和重塑紊乱。脊椎是第二常见的受累部位。本文综述了产生各种影像学表现及其临床相关性所涉及的各种脊柱病理机制和骨动力学。展示了PD在所有椎体成分中的骨、关节和骨髓表现的高级影像学。佩吉特病变常导致包括背痛、椎管狭窄和神经功能障碍在内的临床症状。PD累及引起的各种病理并发症导致了这些临床症状。认识脊柱PD的影像学表现以及导致临床症状的潜在并发症，有助于在进行适当治疗前对患者进行准确评估。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9a/1934928/9d1347b8e496/256_2006_270_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9a/1934928/a0ee895ce0ad/256_2006_270_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9a/1934928/5d364ec510a3/256_2006_270_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9a/1934928/b76fc39ab875/256_2006_270_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9a/1934928/189c31e19704/256_2006_270_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9a/1934928/20de5cd461df/256_2006_270_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9a/1934928/386bac66430e/256_2006_270_Fig14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9a/1934928/cdc639db4774/256_2006_270_Fig15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9a/1934928/bbc5a6fc21f7/256_2006_270_Fig16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9a/1934928/1a35fb35a649/256_2006_270_Fig17_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9a/1934928/12c2becc0726/256_2006_270_Fig20_HTML.jpg

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