White Donald J
The Procter and Gamble Company Mason, OH, USA.
J Clin Dent. 2007;18(1):21-4.
A repeated measures digital imaging technique (Digital Plaque Image Analysis-DPIA) was used to assess the antiplaque effectiveness of a 0.454% stannous fluoride dentifrice.
Subjects were qualified to enter the study based upon a previous assessment of dental plaque accumulation while brushing with a standard (non-antimicrobial) fluoridated dentifrice. Fourteen qualifying subjects were entered into a cross-over study design, including the use of a standard 0.243% sodium fluoride (NaF) dentifrice, or a 0.454% stannous fluoride (SnF,) dentifrice. Cross-over periods were separated by a one-week washout. During the assigned treatments, subjects visited the imaging laboratory on six separate days over two weeks, reporting each day for three separate assessments of plaque accumulation, as assessed by DPIA. On each "grading day," subjects entered for plaque assessments prior to morning tooth brushing, and without consuming any food or beverages. Following this morning "pre-brushing" assessment, subjects brushed with the assigned dentifrice and then had plaque immediately reassessed (morning post-brushing). Subjects also reported to the imaging clinic for an afternoon plaque regrowth assessment. Subjects were again required to avoid food and drink for one hour prior to this measurement.
The SnF2 dentifrice was observed to produce statistically significant reductions in dental plaque, measuring 24.4% in the morning pre-brushing, and 27.9% in the afternoon assessment. Tooth brushing was observed to significantly reduce plaque on the teeth in the morning post-brushing for subjects using either the standard NaF or the SnF2 dentifrice. There were no statistically significant differences in plaque coverage on teeth following tooth brushing with the NaF (6.3% coverage) or SnF2 (6.2% coverage) dentifrices.
Use of a 0.454% SnF2 dentifrice produced statistically significant reductions in dental plaque formation as compared to the similar use of a standard 0.243% NaF dentifrice.
采用重复测量数字成像技术（数字菌斑图像分析-DPIA）评估含0.454%氟化亚锡牙膏的防菌斑效果。
根据之前使用标准（非抗菌）含氟牙膏刷牙时牙菌斑堆积情况的评估，筛选符合条件的受试者进入本研究。14名符合条件的受试者进入交叉研究设计，使用标准的0.243%氟化钠（NaF）牙膏或0.454%氟化亚锡（SnF₂）牙膏。交叉阶段之间有一周的洗脱期。在指定治疗期间，受试者在两周内的六个不同日子到成像实验室就诊，每天进行三次单独的菌斑堆积评估，通过DPIA进行评估。在每个“评分日”，受试者在早晨刷牙前进入实验室进行菌斑评估，且未食用任何食物或饮料。在早晨的“刷牙前”评估后，受试者使用指定的牙膏刷牙，然后立即重新评估菌斑（早晨刷牙后）。受试者还需到成像诊所进行下午菌斑再生长评估。在此测量前，受试者同样需避免进食和饮水一小时。
观察到使用SnF₂牙膏可使牙菌斑产生具有统计学意义的减少，早晨刷牙前减少24.4%，下午评估时减少27.9%。观察到刷牙后，使用标准NaF或SnF₂牙膏的受试者牙齿上的菌斑均显著减少。使用NaF牙膏（覆盖率6.3%）或SnF₂牙膏（覆盖率6.2%）刷牙后，牙齿上的菌斑覆盖率无统计学显著差异。
与使用类似的标准0.243% NaF牙膏相比，使用0.454% SnF₂牙膏可使牙菌斑形成产生具有统计学意义的减少。
