Kasturi R, White D J, Lanzalaco A C, Macksood D, Cox E R, Bacca L, Liang N, Baker R
The Procter and Gamble Company, Sharon Woods Technical Center, Cincinnati, Ohio, USA.
J Clin Dent. 1995;6 Spec No:71-9.
A new stabilized stannous fluoride dentifrice, currently marketed as Crest Gum Care has been examined for its effects on intrinsic plaque metabolic and regrowth activity and effects on plaque resistance to SnF2 throughout nine weeks of toothbrushing. Subjects brushed their teeth 1 X, 2 X or 3 X/day with stabilized stannous fluoride dentifrice or placebo dentifrice for nine weeks, presenting in the morning on weeks 3, 6-9 for plaque sampling. Following nine weeks, subjects were crossed-over and repeated the experiment on their alternative assigned product (active SnF2/placebo). Sampled dental plaques were evaluated for standardized glycolysis and regrowth activity using the "Plaque Glycolysis and Regrowth Method" (PGRM). Following the second nine-week treatment period, subjects concluding either placebo or SnF2 toothbrushing participated in a single-treatment PGRM experiment using stabilized stannous fluoride dentifrice. Toothbrushing with stabilized stannous fluoride dentifrice in this experiment produced significant and sustained reductions in both plaque glycolytic and regrowth activity as compared to placebo treated plaques. In the concluding single-brushing PGRM experiment, SnF2 dentifrice was shown to produce equal inhibitory actions in plaque from subjects completing stannous fluoride or placebo treatments. This result confirmed that nine weeks toothbrushing with stabilized stannous fluoride dentifrice produced no development or resistance of plaque to SnF2 inhibition. These results support the strong in vivo antimicrobial actions of the stabilized stannous fluoride dentifrice, Crest Gum Care.
一种新的稳定型氟化亚锡牙膏，即目前市场上销售的佳洁士牙龈护理牙膏，已在为期九周的刷牙过程中，针对其对牙菌斑内在代谢和再生长活性的影响以及对牙菌斑抗氟化亚锡能力的影响进行了研究。受试者每天使用稳定型氟化亚锡牙膏或安慰剂牙膏刷牙1次、2次或3次，持续九周，并在第3周、第6 - 9周的早晨进行牙菌斑采样。九周后，受试者进行交叉，并用分配给他们的另一种产品（活性氟化亚锡/安慰剂）重复实验。使用“菌斑糖酵解和再生长方法”（PGRM）对采样的牙菌斑进行标准化糖酵解和再生长活性评估。在第二个九周治疗期结束后，完成安慰剂或氟化亚锡刷牙的受试者参加了一项使用稳定型氟化亚锡牙膏的单治疗PGRM实验。与用安慰剂处理的牙菌斑相比，在该实验中使用稳定型氟化亚锡牙膏刷牙可使牙菌斑糖酵解和再生长活性显著且持续降低。在最后的单刷牙PGRM实验中，结果表明氟化亚锡牙膏对完成氟化亚锡或安慰剂治疗的受试者的牙菌斑具有同等的抑制作用。这一结果证实，使用稳定型氟化亚锡牙膏刷牙九周不会使牙菌斑产生对氟化亚锡抑制的耐受性或抗性。这些结果支持了稳定型氟化亚锡牙膏佳洁士牙龈护理牙膏在体内具有强大的抗菌作用。
