乌鲁克他汀A及其两种类似物的合成进展。
Progress towards the synthesis of Urukthapelstatin A and two analogues.
作者信息
Pan Chung-Mao, Lin Chun-Chieh, Kim Seong Jong, Sellers Robert P, McAlpine Shelli R
机构信息
Department of Chemistry and Biochemistry, 5500 Campanile Dr., San Diego State University, San Diego, CA 92182-1030 USA.
出版信息
Tetrahedron Lett. 2012 Aug 8;53(32):4065-4069. doi: 10.1016/j.tetlet.2012.05.105. Epub 2012 May 29.
Abstract
We report our progress towards the synthesis of Urukthapelstatin A (Ustat A) and two analogues. Our retrosynthetic strategy involved the synthesis of three fragments: a tri-heteroaromatic moiety, a phenyl oxazole fragment, and a dipeptide. Described are the syntheses of three unique tri-heteroaromatic moieties. In addition, the corresponding linear precursors of Ustat A and two analogues are presented.
摘要
我们报告了在合成乌鲁克他他汀A（Ustat A）及其两种类似物方面取得的进展。我们的逆合成策略涉及合成三个片段：一个三杂芳基部分、一个苯基恶唑片段和一个二肽。本文描述了三种独特的三杂芳基部分的合成方法。此外，还介绍了Ustat A及其两种类似物的相应线性前体。
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