Vu Te-Dang, Pourcelot Léandre, Nguyen Thi Thanh Binh, Luong Kim-Chi, Sirinelli Dominique, Tranquart François
Université François Rabelais, Inserm U619, Tours Cédex, France.
Ultrasound Med Biol. 2007 May;33(5):672-80. doi: 10.1016/j.ultrasmedbio.2006.10.021. Epub 2007 Apr 6.
Transcranial Doppler has been used previously to determine hemodynamic response to sensorial stimulation in adults but not in the neonatal period. Cerebral blood flow velocity (CBFV) was recorded in both middle cerebral arteries (MCA) and posterior cerebral arteries (PCA) in 100 premature neonates (male 56; female 44; 26 to 36 weeks gestation) from birth to 12 months. Brain development was evaluated on clinical examination. No difference in velocities was noted on prestimulation recordings from birth to 12 months. During light stimulation before six months, the CBFV was reduced (-11 +/- 6% in MCA and -13 +/- 5% in PCA compared with baseline values). After stimulation, the CBFV was increased (+6.7 +/- 3% in MCA and + 10.5 +/- 4% in PCA compared with baseline values). This study is in favor of cortex maturation in normal premature neonates at only six months. Consequently, functional transcranial Doppler technique will be helpful for the diagnosis of abnormal maturation timing in neonates with possible developmental retardation.
经颅多普勒先前已用于确定成年人对感觉刺激的血流动力学反应，但未用于新生儿期。对100例早产新生儿（男56例，女44例；胎龄26至36周）从出生至12个月期间记录大脑中动脉（MCA）和大脑后动脉（PCA）的脑血流速度（CBFV）。通过临床检查评估大脑发育情况。从出生至12个月的预刺激记录中未发现速度差异。在6个月前的光刺激期间，CBFV降低（与基线值相比，MCA降低-11±6%，PCA降低-13±5%）。刺激后，CBFV升高（与基线值相比，MCA升高+6.7±3%，PCA升高+10.5±4%）。本研究支持正常早产新生儿仅在6个月时皮质成熟。因此，功能性经颅多普勒技术将有助于诊断可能发育迟缓的新生儿成熟时间异常。
