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针对传染性威胁的防范:公私合作开发针对突发威胁的平价疫苗:三价脑膜炎奈瑟菌ACW135多糖疫苗

Preparedness for infectious threats: public-private partnership to develop an affordable vaccine for an emergent threat: the trivalent Neisseria meningitidis ACW135 polysaccharide vaccine.

作者信息

Nelson Christopher B, Birmingham Maureen, Costa Alejandro, Daviaud Joelle, Perea William, Kieny Marie-Paule, Tarantola Daniel

机构信息

Department of Immunizations, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland.

出版信息

Am J Public Health. 2007 Apr;97 Suppl 1(Suppl 1):S15-22. doi: 10.2105/AJPH.2005.075085. Epub 2007 Apr 5.

DOI:10.2105/AJPH.2005.075085
PMID:17413077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1854992/
Abstract

With the emergence of epidemic Neisseria meningitidis W135 meningitis in Burkina Faso during early 2002, the public health community was faced with the challenge of providing access to an appropriate and affordable vaccine in time for the upcoming 2003 epidemic season. Recognizing the implications of the emergent threat, the World Health Organization developed a strategy, established a public-private partnership to provide the needed vaccine, and then ensured that a stockpile was available for future use. The trivalent N meningitidis ACW135 polysaccharide vaccine that resulted is now one of the primary tools for epidemic response in African meningitis belt countries. It will remain so for the foreseeable future and until appropriate and affordable conjugate vaccines become part of national immunization programs in the region.

摘要

2002年初布基纳法索出现流行性脑膜炎奈瑟菌W135脑膜炎疫情,公共卫生界面临一项挑战,即要及时提供一种适宜且价格合理的疫苗,以应对即将到来的2003年流行季节。认识到这一突发威胁的影响后,世界卫生组织制定了一项战略,建立了公私伙伴关系以提供所需疫苗,随后确保储备有疫苗供未来使用。由此产生的三价A、C、W135群脑膜炎奈瑟菌多糖疫苗,现已成为非洲脑膜炎带国家应对疫情的主要工具之一。在可预见的未来,直至适宜且价格合理的结合疫苗成为该地区国家免疫规划的一部分之前,它都将保持这一地位。

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本文引用的文献

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Monitoring of adverse events during the 2003 mass vaccination campaign with a trivalent meningococcal A/C/W135 polysaccharide vaccine in Burkina Faso.2003年布基纳法索使用三价A/C/W135群脑膜炎球菌多糖疫苗开展大规模疫苗接种运动期间的不良事件监测。
Vaccine. 2007 Sep 3;25 Suppl 1:A72-8. doi: 10.1016/j.vaccine.2007.04.045. Epub 2007 May 7.
2
The first large epidemic of meningococcal disease caused by serogroup W135, Burkina Faso, 2002.2002年,布基纳法索首次出现由W135群脑膜炎球菌引起的大规模疫情。
Vaccine. 2007 Sep 3;25 Suppl 1:A37-41. doi: 10.1016/j.vaccine.2007.04.038. Epub 2007 May 7.
3
An evaluation of the immunogenicity and safety of a new trivalent meningococcal polysaccharide vaccine.一种新型三价脑膜炎球菌多糖疫苗的免疫原性和安全性评估。
Vaccine. 2007 Sep 3;25 Suppl 1:A83-91. doi: 10.1016/j.vaccine.2007.04.047. Epub 2007 May 7.
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Risk mapping and early warning systems for the control of meningitis in Africa.非洲脑膜炎控制的风险地图绘制与早期预警系统
Vaccine. 2007 Sep 3;25 Suppl 1:A12-7. doi: 10.1016/j.vaccine.2007.04.034. Epub 2007 May 7.
5
Effectiveness of a trivalent serogroup A/C/W135 meningococcal polysaccharide vaccine in Burkina Faso, 2003.2003年,三价A/C/W135群脑膜炎球菌多糖疫苗在布基纳法索的有效性。
Vaccine. 2007 Sep 3;25 Suppl 1:A92-6. doi: 10.1016/j.vaccine.2007.04.048. Epub 2007 May 7.
6
Prospects for vaccine prevention of meningococcal infection.脑膜炎球菌感染疫苗预防的前景。
Clin Microbiol Rev. 2006 Jan;19(1):142-64. doi: 10.1128/CMR.19.1.142-164.2006.
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Health conditions for travellers to Saudi Arabia pilgrimage to Mecca (Hajj).前往沙特阿拉伯麦加朝觐的旅行者的健康状况。
Wkly Epidemiol Rec. 2005 Dec 9;80(49-50):431-2.
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Bull World Health Organ. 2005 Apr;83(4):301-7. Epub 2005 Apr 25.
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APMIS. 2005 Mar;113(3):182-6. doi: 10.1111/j.1600-0463.2005.apm1130305.x.
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