Jin Hyun-Seung, Kim Hyo Bin, Kim Bong Seong, Lee Jong-Keuk, Seo Eul-Ju, Yoo Han-Wook, Park In Sook, Hong Young Mi, Hong Soo-Jong
Department of Pediatrics, College of Medicine, Ulsan University, Asian Medical Center, Seoul 138-736, Korea.
Pediatr Res. 2007 May;61(5 Pt 1):584-7. doi: 10.1203/pdr.0b013e3180459fb5.
Kawasaki disease (KD) is an acute febrile vasculitic syndrome of unknown etiology that preferentially affects the coronary artery. Interleukin-10 (IL-10) is a key proinflammatory cytokine, and a polymorphism near the major transcriptional start site of the IL-10 gene was shown to influence IL-10 production in vitro. This study investigated the association of the IL-10 promoter polymorphism with KD and its clinical parameters in Korean children. A total of 194 children with congenital heart disease (CHD) and 95 children with KD were included in this study. IL-10 (-627 A/C) polymorphism genotypes were determined using the single-base extension method. There was no difference in the allele frequencies of IL-10 (-627 A/C) polymorphism between CHD children and KD children. KD children with one or two copies of the IL-10 (-627C) allele showed significantly lower albumin levels (p = 0.020) and higher frequencies of early coronary artery aneurysm [62.22% versus 37.78%, adjusted odds ratio (aOR) = 3.50, 95% confidence interval (CI): 1.50-8.16] compared with KD children with the common IL-10 (-627A) allele. These findings suggest that the IL-10 (-627 A/C) promoter polymorphism might be a genetic marker for the risk of early coronary artery complication in KD.
川崎病（KD）是一种病因不明的急性发热性血管炎综合征，主要累及冠状动脉。白细胞介素-10（IL-10）是一种关键的促炎细胞因子，IL-10基因主要转录起始位点附近的多态性已被证明在体外会影响IL-10的产生。本研究调查了韩国儿童中IL-10启动子多态性与KD及其临床参数之间的关联。本研究共纳入了194名先天性心脏病（CHD）儿童和95名KD儿童。采用单碱基延伸法测定IL-10（-627 A/C）多态性基因型。CHD儿童和KD儿童之间IL-10（-627 A/C）多态性的等位基因频率没有差异。与具有常见IL-10（-627A）等位基因的KD儿童相比，具有一个或两个IL-10（-627C）等位基因拷贝的KD儿童白蛋白水平显著降低（p = 0.020），早期冠状动脉瘤的发生率更高[62.22%对37.78%，调整后的优势比（aOR）= 3.50，95%置信区间（CI）：1.50 - 8.16]。这些发现表明，IL-10（-627 A/C）启动子多态性可能是KD早期冠状动脉并发症风险的一个遗传标志物。
