Jhang Won Kyoung, Kang Mi-Jin, Jin Hyun-Seung, Yu Jinho, Kim Byoung-ju, Kim Bong Seong, Lee Jong-Keuk, Seo Eul-Ju, Yoo Han-Wook, Park In Sook, Hong Young Mi, Hong Soo-Jong
Department of Pediatrics, Asan Medical Center, College of Medicine, Ulsan University, Seoul, South Korea.
J Clin Immunol. 2009 Jan;29(1):22-8. doi: 10.1007/s10875-008-9218-z. Epub 2008 Jul 15.
Kawasaki disease (KD) is an acute vasculitis syndrome of unknown etiology that frequently affects small to medium size arteries. C-C chemokine receptor 5 (CCR5) is a chemokine receptor that binds C-C chemokines. This study investigated the association of the CCR5 (-2135C/T) polymorphism with KD in Korean children.
The study population consisted 189 Korean children with KD and 194 Korean children with congenital heart disease (CHD). CCR5 (-2135C/T) polymorphism genotypes were determined using the single-base extension method.
The allele frequencies of the CCR5 (-2135C/T) polymorphism differed significantly between CHD children and KD children (-2135T/T, 16.75% vs. 30.05%, aOR 2.14, 95% CI 1.31-3.51). The tested laboratory parameters differed significantly between the KD and CHD groups. The development of coronary artery aneurysm in KD patients was not associated with the CCR5 polymorphism.
Our findings suggest that the T allele at the CCR5 (-2135C/T) polymorphism might be associated with the development of KD in Korean children but does not appear to be associated with the development of coronary artery aneurysm.
川崎病（KD）是一种病因不明的急性血管炎综合征，常累及中小动脉。C-C趋化因子受体5（CCR5）是一种与C-C趋化因子结合的趋化因子受体。本研究调查了韩国儿童中CCR5（-2135C/T）多态性与川崎病的关联。
研究人群包括189名患川崎病的韩国儿童和194名患先天性心脏病（CHD）的韩国儿童。采用单碱基延伸法确定CCR5（-2135C/T）多态性基因型。
CCR5（-2135C/T）多态性的等位基因频率在患先天性心脏病儿童和患川崎病儿童之间存在显著差异（-2135T/T，16.75%对30.05%，调整后比值比2.14，95%可信区间1.31 - 3.51）。川崎病组和先天性心脏病组之间的检测实验室参数存在显著差异。川崎病患者冠状动脉瘤的发生与CCR5多态性无关。
我们的研究结果表明，CCR5（-2135C/T）多态性中的T等位基因可能与韩国儿童川崎病的发生有关，但似乎与冠状动脉瘤的发生无关。
