Villella Jeannine, Herrmann Francois R, Kaul Sadhana, Lele Shashikant, Marchetti David, Natiella Joan, Odunsi Kunle, Mhawech-Fauceglia Paulette
Department of Gynecologic Oncology Surgery, Roswell Park Cancer Institute, Buffalo, New York 12463, USA.
Int J Gynecol Pathol. 2007 Apr;26(2):154-9. doi: 10.1097/01.pgp.0000228143.52054.46.
Granulosa cell tumor (GCT) is a rare neoplasm hallmarked by a very indolent course and late recurrences. Although numerous clinical and pathological parameters have been implicated as prognostic factors for GCT, their role remains controversial. We performed a retrospective study at our institution where we identified 48 patients with GCT from our tumor registry. Demographic and clinical course information was recorded from the medical record. Twenty of 48 formalin-fixed, paraffin-embedded blocks were retrieved from archived specimens. Pathological parameters such as nuclear atypia, mitotic count, Ki-67 index using immunohistochemistry, and quantitative DNA ploidy were performed. DNA aneuploidy by quantitative method was associated with patients' overall survival. The degree of nuclear atypia, mitotic count, Ki-67 index, and DNA aneuploidy was not predictive of tumor recurrence. Multi-institutional collaboration is imperative to create a comprehensive national database for investigation into ways that may better indicate prognosis in these patients.
颗粒细胞瘤（GCT）是一种罕见的肿瘤，其特点是病程极为缓慢且复发较晚。尽管众多临床和病理参数已被认为是GCT的预后因素，但其作用仍存在争议。我们在本机构进行了一项回顾性研究，从肿瘤登记处识别出48例GCT患者。从病历中记录人口统计学和临床病程信息。从存档标本中检索出48个福尔马林固定、石蜡包埋的组织块中的20个。进行了病理参数检测，如核异型性、有丝分裂计数、采用免疫组织化学法检测Ki-67指数以及定量DNA倍体分析。通过定量方法检测的DNA非整倍体与患者的总生存期相关。核异型性程度、有丝分裂计数、Ki-67指数和DNA非整倍体并不能预测肿瘤复发。多机构合作对于创建一个全面的国家数据库以研究可能更好地指示这些患者预后的方法至关重要。
