Roush G R, el-Naggar A K, Abdul-Karim F W
Institute of Pathology, Case Western Reserve University, and University Hospitals of Cleveland, Ohio 44106, USA.
Gynecol Oncol. 1995 Mar;56(3):430-4. doi: 10.1006/gyno.1995.1076.
Flow cytometric DNA ploidy and S-phase fraction (SPF) analysis was performed on 18 granulosa cell tumors of the ovary. Clinical and pathologic data from patients followed for an average of 10 years were compared to flow cytometry ploidy to determine its prognostic usefulness. Eleven (62%) tumors were diploid and seven (38%) were aneuploid. Aneuploidy was significantly associated with high stage, vascular or capsular invasion, and nuclear atypia but not with SPF or necrosis. Of the patients on whom follow-up was available, only 1 of 10 (10%) with euploid tumors died of disease, while 4 of 5 (80%) with aneuploid tumors died of their disease; this, however, did not reach a significant statistical correlation. SPF was not correlated with any clinical or histologic parameter. Aneuploidy in granulosa cell tumors is associated with other adverse histopathologic parameters and an apparent trend toward aggressive behavior.
对18例卵巢颗粒细胞瘤进行了流式细胞术DNA倍体和S期分数（SPF）分析。将平均随访10年的患者的临床和病理数据与流式细胞术倍体进行比较，以确定其预后价值。11例（62%）肿瘤为二倍体，7例（38%）为非整倍体。非整倍体与高分期、血管或包膜侵犯以及核异型性显著相关，但与SPF或坏死无关。在有随访资料的患者中，10例（10%）二倍体肿瘤患者中只有1例死于疾病，而5例（80%）非整倍体肿瘤患者中有4例死于疾病；然而，这并未达到显著的统计学相关性。SPF与任何临床或组织学参数均无相关性。卵巢颗粒细胞瘤中的非整倍体与其他不良组织病理学参数以及明显的侵袭性行为趋势相关。
