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Cognitive side effects of valproic acid-induced hyperammonemia in children with epilepsy.

作者信息

Nicolai Joost, Aldenkamp Albert P, Huizenga Johannes R, Teune Laura K, Brouwer Oebele F

出版信息

J Clin Psychopharmacol. 2007 Apr;27(2):221-4. doi: 10.1097/01.jcp.0000264973.77581.61.

DOI:10.1097/01.jcp.0000264973.77581.61
PMID:17414255
Abstract
摘要

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4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy.4217C>A 基因点突变与丙氨酰-琥珀酸合成酶 1 基因可能与基于丙戊酸治疗期间的高氨血症发展无关。
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Valproate induces non-hyperammonemic encephalopathy below a standard serum concentration range: A case report.丙戊酸盐在标准血清浓度范围以下诱发非高氨血症性脑病：一例报告。
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