Murphy E Angela, Davis J Mark, Brown Adrienne S, Carmichael Martin D, Ghaffar Abdul, Mayer Eugene P
Divison of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
Med Sci Sports Exerc. 2007 Apr;39(4):639-44. doi: 10.1249/mss.0b013e3180306309.
Fatiguing exercise has been associated with a decrease in certain functions of neutrophils, whereas moderate exercise has generally been associated with an increase. Consumption of oat beta-glucan (ObetaG), a soluble fiber and mild immune system enhancer, may offset the immunosuppression associated with intense training and perhaps further enhance the benefits of moderate exercise.
To test the effects of ObetaG consumption on neutrophil function and number after both moderate and fatiguing exercise.
Male mice were assigned to one of six treatment groups. Fatiguing exercise mice (Ftg-ObetaG and Ftg-H2O) ran to volitional fatigue on a treadmill for three consecutive days, and moderate exercise mice (Mod-ObetaG and Mod-H2O) ran for six consecutive days for 1 h. Control mice (Con-ObetaG and Con-H2O) were exposed to the treadmill environment but did not run. ObetaG was consumed in the drinking water (approximately 0.6 mL x d(-1)) for 10 consecutive days. After rest or exercise on the last day of training, mice were given a 1-mL i.p. injection of thioglycollate. Mice were sacrificed 3 h later; neutrophils were harvested from the peritoneal cavity and counted, and their respiratory burst activity was measured using flow cytometry.
Both moderate exercise and ObetaG increased neutrophil burst activity, whereas fatiguing exercise had no effect. Neutrophil number was increased by fatiguing exercise and ObetaG, but not moderate exercise. There were no additive effects of exercise and ObetaG on either of these variables.
These data suggest that although not additive in their effects, both ObetaG and exercise can alter overall neutrophil respiratory burst activity (number and/or function), but only ObetaG increased both number and function, which may have important ramifications for defense against infection.
疲劳运动与中性粒细胞某些功能的下降有关，而适度运动通常与中性粒细胞功能的增强有关。燕麦β-葡聚糖（ObetaG）是一种可溶性纤维和轻度免疫系统增强剂，其摄入可能抵消与高强度训练相关的免疫抑制作用，并且可能进一步增强适度运动的益处。
测试摄入ObetaG对适度运动和疲劳运动后中性粒细胞功能和数量的影响。
将雄性小鼠分为六个治疗组之一。疲劳运动组小鼠（Ftg-ObetaG和Ftg-H2O）连续三天在跑步机上跑至自愿疲劳，适度运动组小鼠（Mod-ObetaG和Mod-H2O）连续六天每天跑1小时。对照组小鼠（Con-ObetaG和Con-H2O）暴露于跑步机环境但不跑步。连续10天通过饮用水摄入ObetaG（约0.6 mL·d⁻¹）。在训练的最后一天休息或运动后，给小鼠腹腔注射1 mL硫代乙醇酸盐。3小时后处死小鼠；从腹腔收集中性粒细胞并计数，使用流式细胞术测量其呼吸爆发活性。
适度运动和ObetaG均增加了中性粒细胞的爆发活性，而疲劳运动则无此作用。疲劳运动和ObetaG增加了中性粒细胞数量，但适度运动未增加。运动和ObetaG对这两个变量均无相加作用。
这些数据表明，尽管ObetaG和运动的作用并非相加，但二者均可改变中性粒细胞的总体呼吸爆发活性（数量和/或功能），但只有ObetaG增加了数量和功能，这可能对防御感染具有重要意义。
