Aaltonen Katri, Laurikka Pilvi, Huhtala Heini, Mäki Markku, Kaukinen Katri, Kurppa Kalle
Center for Child Health Research, Tampere University Hospital, 33521 Tampere, Finland.
The Faculty of Medicine and Life Sciences, University of Tampere, 33014 Tampere, Finland.
Nutrients. 2017 Jun 15;9(6):611. doi: 10.3390/nu9060611.
A strict gluten-free diet (GFD) can be diversified by non-contaminated oats, but there is a shortage of long-term studies concerning its safety. We compared long-term treatment outcomes and factors associated with the introduction of oats between celiac patients on a GFD with or without oats. Eight hundred sixty-nine previously diagnosed celiac patients were interviewed. The validated Gastrointestinal Symptom Rating Scale (GSRS), Psychological General Well-Being (PGWB), and Short-Form 36 Health Survey (SF-36) questionnaires were used to assess symptoms and quality of life, serological tests were performed, and results of histology were confirmed from patient records. We found the median duration of GFD to be 10 years and 82% using oats. Factors predicting the consumption of oats were diagnosis after the year 2000, advice from a dietitian, detection by screening, and mild clinical presentation. Oat consumers and non-consumers did not differ in dietary adherence (96.5% vs. 97.4%, = 0.746), the prevalence of symptoms (22.9% vs. 22.5%, = 0.931), positivity for endomysial antibodies (8.8% vs. 6.0%, = 0.237), histological recovery after one year (63.1% vs. 60.0%, = 0.773), malignancy (4.8% vs. 3.3%, = 0.420), osteoporosis/osteopenia (9.2% vs. 11.0%, = 0.489), or fractures (26.9% vs. 27.9%, = 0.791). The oat consumers had better SF-36 physical role limitations and general health scores. Based on our results, the long-term consumption of oats in celiac disease patients is safe and may improve quality of life.
严格的无麸质饮食（GFD）可以通过未受污染的燕麦来多样化，但关于其安全性的长期研究却很缺乏。我们比较了食用或不食用燕麦的乳糜泻患者在长期治疗结果以及与引入燕麦相关的因素。对869名先前诊断为乳糜泻的患者进行了访谈。使用经过验证的胃肠道症状评分量表（GSRS）、心理总体幸福感（PGWB）和简明健康调查36项量表（SF-36）问卷来评估症状和生活质量，进行了血清学检测，并从患者记录中确认了组织学结果。我们发现GFD的中位持续时间为10年，82%的患者食用燕麦。预测食用燕麦的因素包括2000年后的诊断、营养师的建议、筛查检测以及轻度临床表现。食用燕麦者和不食用燕麦者在饮食依从性（96.5%对97.4%，P = 0.746）、症状患病率（22.9%对22.5%，P = 0.931）、肌内膜抗体阳性率（8.8%对6.0%，P = 0.237）、一年后的组织学恢复情况（63.1%对60.0%，P = 0.773）、恶性肿瘤（4.8%对3.3%，P = 0.420）、骨质疏松症/骨质减少症（9.2%对11.0%，P = 0.489）或骨折（26.9%对27.9%，P = 0.791）方面没有差异。食用燕麦者的SF-36身体功能受限和总体健康评分更好。根据我们的结果，乳糜泻患者长期食用燕麦是安全的，并且可能改善生活质量。
