Ghadimi Reza, Taheri Hassan, Suzuki Sadao, Kashifard Mehrdad, Hosono Akihiro, Esfandiary Imaneh, Moghadamnia Ali A, Ghadimi Rezvan, Tokudome Shinkan
Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Eur J Cancer Prev. 2007 Jun;16(3):192-5. doi: 10.1097/01.cej.0000220639.61717.67.
To clarify host and environmental factors for gastric carcinogenesis, we obtained information about gastric cancer mortality in Babol, in the North of Iran, and recruited 130 participants aged 30-80 years from the general population of Babol in 2004. A urea breath test, assessment of IgG antibodies to Helicobacter pylori, a pepsinogen test, a marker of chronic atrophic gastritis, and determination of urinary excretions of sodium and potassium were performed. Diet and lifestyle information was also obtained using a questionnaire. The stomach cancer mortality rate for men in Babol (38.2/10(5)) was found to be somewhat lower than that for Japanese men (45.1/10(5)), while the mortality for women (26.9/10(5)) was higher than for Japanese women (20.9/10(5)). Positive rates for the urea breath test were 77.5 and 81.8% for Iranian men and women, respectively. Helicobacter pylori IgG antibodies were present in 68.7 and 73.7% of Iranian men and women, respectively, both values being marginally higher than for Japanese. We also found 51.0 and 52.8% to be positive for a pepsinogen test, significantly higher than the Japanese values. Urinary excretions of salt and potassium in this population appeared approximately the same as the consumption in Japanese. The elevated gastric cancer mortality in both men and women in Babol seems, by and large, to be related to higher H. pylori infection rates and prevalence of chronic atrophic gastritis. Certain factors, including H. pylori DNA diversity, host factors and their interactions, together with the level of medical practice, prevalence of and access to secondary prevention of stomach cancer, may also be associated with the relatively high mortality.
为了阐明胃癌发生的宿主和环境因素，我们获取了伊朗北部巴博勒市胃癌死亡率的相关信息，并于2004年从巴博勒市普通人群中招募了130名年龄在30至80岁之间的参与者。进行了尿素呼气试验、幽门螺杆菌IgG抗体评估、胃蛋白酶原检测（慢性萎缩性胃炎的一项指标）以及尿钠和尿钾排泄量的测定。还通过问卷调查获取了饮食和生活方式信息。结果发现，巴博勒市男性的胃癌死亡率（38.2/10⁵）略低于日本男性（45.1/10⁵），而女性死亡率（26.9/10⁵）高于日本女性（20.9/10⁵）。伊朗男性和女性的尿素呼气试验阳性率分别为77.5%和81.8%。伊朗男性和女性中幽门螺杆菌IgG抗体阳性率分别为68.7%和73.7%，这两个数值略高于日本。我们还发现胃蛋白酶原检测阳性率分别为51.0%和52.8%，显著高于日本的数值。该人群的尿盐和尿钾排泄量与日本的摄入量大致相同。总体而言，巴博勒市男性和女性胃癌死亡率升高似乎与幽门螺杆菌感染率较高以及慢性萎缩性胃炎患病率较高有关。某些因素，包括幽门螺杆菌DNA多样性、宿主因素及其相互作用，以及医疗实践水平、胃癌二级预防的患病率和可及性，可能也与相对较高的死亡率有关。
