Tokudome Shinkan, Samsuria Soeripto Witjitra D, Triningsih F X Ediati, Suzuki Sadao, Hosono Akihiro, Triono Teguh, Sarjadi Indra Wijaya, Miranti Ika P, Ghadimi Reza, Moore Malcolm A
Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya 467-8601, Japan.
Cancer Sci. 2005 Dec;96(12):873-5. doi: 10.1111/j.1349-7006.2005.00122.x.
The gastric cancer incidence in Semarang, Indonesia, is exceedingly low: only approximately 1/100th of the level in Japan. To elucidate the reason, we carried out an ecological study recruiting 69 male and 102 female participants from the general populace in January 2005. Positive urea breath tests were 0% for both men and women, and Helicobacter pylori (H. pylori) IgG antibodies were found in 2% (0-5, 95% confidence interval) of men and 2% (0-4) of women, significantly lower than the 62% (58-65) and 57% (53-60), respectively, in Japan. Furthermore, there were no positive findings with the pepsinogen tests in Semarang, again significant in comparison with the 23% (22-25) and 22% (20-23) in Japan. Variation in smoking levels and consumption of NaCl, vegetables and fruit were found, but not to an extent that would allow explanation of the major differences in gastric cancer incidence. We may conclude that the very low prevalence of H. pylori infection and thus chronic atrophic gastritis account for the rarity of stomach cancer in Semarang, Indonesia.
仅约为日本发病率的1/100。为阐明原因，我们于2005年1月开展了一项生态学研究，从普通人群中招募了69名男性和102名女性参与者。男性和女性的尿素呼气试验阳性率均为0%，男性中幽门螺杆菌（H. pylori）IgG抗体阳性率为2%（0 - 5，95%置信区间），女性为2%（0 - 4），显著低于日本男性的62%（58 - 65）和女性的57%（53 - 60）。此外，三宝垄的胃蛋白酶原检测未发现阳性结果，与日本的23%（22 - 25）和22%（20 - 23）相比，差异也很显著。虽然发现了吸烟水平以及氯化钠、蔬菜和水果摄入量存在差异，但程度不足以解释胃癌发病率的主要差异。我们可以得出结论，幽门螺杆菌感染率极低，进而慢性萎缩性胃炎发病率低，是印度尼西亚三宝垄胃癌罕见的原因。
