N-二十二碳六烯酰多巴胺的抗氧化和神经保护特性。
Antioxidant and neuroprotective properties of N-docosahexaenoyl dopamine.
作者信息
Bobrov M Yu, Lyzhin A A, Andrianova E L, Gretskaya N M, Zinchenko G N, Frumkina L E, Khaspekov L G, Bezuglov V V
机构信息
Laboratory of Oxylipins, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
出版信息
Bull Exp Biol Med. 2006 Oct;142(4):425-7. doi: 10.1007/s10517-006-0383-x.
N-Docosahexaenoyl dopamine exhibited antioxidant activity in the test with a stable oxygen radical galvinoxyl. This compound produced a dose-dependent protective effect on cultured granular cells from rat cerebellum under conditions of oxidative stress. N-Docosahexaenoyl dopamine decelerated the development of symptoms of Parkinson's disease in mice receiving neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
N-二十二碳六烯酰多巴胺在与稳定氧自由基加尔文oxyl的测试中表现出抗氧化活性。该化合物在氧化应激条件下对大鼠小脑培养的颗粒细胞产生剂量依赖性保护作用。N-二十二碳六烯酰多巴胺减缓了接受神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶的小鼠帕金森病症状的发展。
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