Müller-Quernheim J, Pfeifer S, Strausz J, Ferlinz R
IIIrd Department of Internal Medicine, Johannes Gutenberg University, Mainz, Federal Republic of Germany.
Am Rev Respir Dis. 1991 Dec;144(6):1322-9. doi: 10.1164/ajrccm/144.6.1322.
The evaluation of activation markers such as T4/T8 ratio and HLA-DR expression of lymphocytes of bronchoalveolar lavage (L-BAL) is an important clinical approach for the staging of sarcoidosis. However, it is not known to what extent this is paralleled by an exaggerated lymphocyte function. We investigated the dependence of L-BAL activation markers on the production of interleukin-2 (IL-2) by L-BAL and on the soluble IL-2 receptor serum level (sIL-2R) in 116 patients with sarcoidosis. In none of the combinations tested was a correlation between the two groups of parameters found; r less than 0.5, upper 90% confidence limit of r less than 0.8. Interestingly, IL-2 production is independent of HLA-DR+ T4 L-BAL, and sIL-2R production is independent of the percentage of IL-2+ L-BAL. Our data indicate that the L-BAL activation markers and the functional activity of T-cells represent independent phenomena.
评估支气管肺泡灌洗淋巴细胞（L-BAL）的激活标志物，如T4/T8比值和HLA-DR表达，是结节病分期的重要临床方法。然而，目前尚不清楚这在多大程度上与淋巴细胞功能亢进平行。我们在116例结节病患者中研究了L-BAL激活标志物与L-BAL白细胞介素-2（IL-2）产生以及可溶性IL-2受体血清水平（sIL-2R）之间的相关性。在所测试的任何组合中，均未发现两组参数之间存在相关性；r小于0.5，r的90%置信上限小于0.8。有趣的是，IL-2的产生独立于HLA-DR+T4 L-BAL，而sIL-2R的产生独立于IL-2+L-BAL的百分比。我们的数据表明，L-BAL激活标志物和T细胞的功能活性代表独立的现象。
