Xaubet A, Agustí C, Roca J, Picado C, Rodriguez-Roisin R
Servei de Pneumologia, Hospital Clinic, Facultat de Medicina, Universitat de Barcelona, Spain.
Eur Respir J. 1993 May;6(5):715-8.
To investigate the relationship [corrected] between immunocytological features of bronchoalveolar lavage (BAL) and clinical indices in sarcoidosis, we studied the lymphocyte subsets, as well as the expression of human leucocyte antigen-DR (HLA-DR) and interleukin 2 receptor (IL-2R) antigens in BAL lymphocytes. We studied 16 patients with untreated sarcoidosis and 12 control subjects. We found significantly higher absolute numbers of lymphocytes bearing the IL-2R antigen in sarcoidosis. A stronger difference between groups was observed in both the percentage and absolute numbers of HLA-DR+ lymphocytes. We also found a moderate but significant correlation between the number of lymphocytes expressing the activation antigens and single breath carbon monoxide diffusing capacity in patients with sarcoidosis: DLCO vs HLA-DR+ lymphocytes (r = -0.60); DLCO vs IL-2R+ lymphocytes (r = -0.62); carbon monoxide transfer coefficient (KCO vs HLA-DR+ lymphocytes (r = -0.53); and KCO vs IL-2R+ lymphocytes (r = -0.58). Our results suggest that the reduction in diffusing capacity, expressed as either DLCO or KCO, results from the severity of alveolitis in mild to moderate sarcoidosis.
为了研究结节病中支气管肺泡灌洗（BAL）的免疫细胞学特征与临床指标之间的关系，我们研究了BAL淋巴细胞中的淋巴细胞亚群，以及人类白细胞抗原-DR（HLA-DR）和白细胞介素2受体（IL-2R）抗原的表达。我们研究了16例未经治疗的结节病患者和12名对照受试者。我们发现结节病中携带IL-2R抗原的淋巴细胞绝对数量显著更高。在HLA-DR+淋巴细胞的百分比和绝对数量上，两组之间观察到更强的差异。我们还发现结节病患者中表达活化抗原的淋巴细胞数量与单次呼吸一氧化碳弥散能力之间存在中度但显著的相关性：一氧化碳弥散量（DLCO）与HLA-DR+淋巴细胞（r = -0.60）；DLCO与IL-2R+淋巴细胞（r = -0.62）；一氧化碳转运系数（KCO）与HLA-DR+淋巴细胞（r = -0.53）；以及KCO与IL-2R+淋巴细胞（r = -0.58）。我们的结果表明，以DLCO或KCO表示的弥散能力降低是由轻度至中度结节病中肺泡炎的严重程度所致。
