球孢白僵菌ATCC 7159对单性豆素的代谢
Metabolism of parthenin by Beauveria bassiana ATCC 7159.
作者信息
Abdel Halim O B, Maatooq G T, Marzouk A M
机构信息
Department of Pharmacognosy, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt.
出版信息
Pharmazie. 2007 Mar;62(3):226-30.
Two new metabolites were isolated from the biotransformation reaction of parthenin by Beauveria bassiana ATCC 7159 along with the known naturally occurring sesquiterpene lactones hymenolin and dihydrocoronopilin. The new metabolites: are 3beta,4beta,6beta-trihydroxy-10alphaH,11alpha-methyl-ambrosa-1 -en-12-oic acid-gamma-lactone and 3alpha,6beta-dihydroxy-4beta-hydroperoxy-10alphaH, 11alpha-methyl-ambrosa-1-en-12-oic acid-gamma-lactone. The structure elucidation of these compounds was achieved by different spectroscopic methods.
球孢白僵菌ATCC 7159对小白菊内酯进行生物转化反应时，分离得到了两种新的代谢产物，以及已知的天然倍半萜内酯膜边草酸和二氢冠刺素。新的代谢产物为：3β,4β,6β-三羟基-10αH,11α-甲基-豚草-1-烯-12-酸-γ-内酯和3α,6β-二羟基-4β-氢过氧基-10αH,11α-甲基-豚草-1-烯-12-酸-γ-内酯。通过不同的光谱方法对这些化合物进行了结构解析。
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