紫杉烷类化合物的微生物转化及其抗氧化活性转化产物的评价。

Microbial transformation of podocarpic acid and evaluation of transformation products for antioxidant activity.

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

出版信息

Planta Med. 2010 May;76(8):815-7. doi: 10.1055/s-0029-1240738. Epub 2010 Jan 12.

PMID:20072957

Abstract

Podocarpic acid was metabolized by Mucor ramannianus ATCC 9628, and Beauveria bassiana ATCC 7159 to afford two new metabolites, 2 alpha-hydroxy podocarpic acid and 11-hydroxy podocarpic acid, along with the known metabolite 13-hydroxy podocarbic acid. The identity of these metabolites was verified using different spectral methods. The antioxidant activity of the metabolites was tested, and comparable results to those observed for ascorbic acid were obtained.

摘要

罗汉松酸被根毛霉（Mucor ramannianus）ATCC 9628 和球孢白僵菌（Beauveria bassiana）ATCC 7159 代谢，生成了两个新的代谢产物，2α-羟基罗汉松酸和 11-羟基罗汉松酸，以及已知的代谢产物 13-羟基罗汉松酸。这些代谢产物的身份通过不同的光谱方法得到了验证。还测试了代谢产物的抗氧化活性，得到了与抗坏血酸相似的结果。