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中国农村高血压人群血脂异常患病率及相关因素

Prevalence of dyslipidemia and associated factors among the hypertensive rural chinese population.

作者信息

Zhang Xingang, Sun Zhaoqing, Zheng Liqiang, Li Jue, Liu Shuangshuang, Xu Changlu, Li Jiajin, Zhao Fenfen, Hu Dayi, Sun Yingxian

机构信息

Department of Cardiology, The Second Affiliated Hospital of China Medical University, Shenyang, P.R. China.

出版信息

Arch Med Res. 2007 May;38(4):432-9. doi: 10.1016/j.arcmed.2006.12.005.

Abstract

BACKGROUND

Dyslipidemia plays a crucial rule in the development of cardiovascular disease, which has become the leading cause of death in most developed countries as well as in developing countries. This study was designed to investigate the epidemiological features of dyslipidemia in rural adults with hypertension in China.

METHODS

A cross-sectional survey was conducted during 2004-2006 through a cluster multistage sampling to a resident group of 6,412 individuals (2,805 men, 3,607 women) with hypertension, aged >/=35 years, in the countryside of Liaoning, China. Serum lipids levels were proposed by National Cholesterol Education Program Adult Treatment Panel III.

RESULTS

Of the study population 34.4% had borderline high total cholesterol (TC), 16.9% had high TC, and 8.8% had low high-density lipoprotein cholesterol (HDL-C). The population with borderline high, high, and very high low-density lipoprotein cholesterol (LDL-C) was 15.7, 3.5, and 0.9%, respectively. In addition, 15.9% had borderline high triglycerides (TG), 17.8% had high TG and 2.0% had very high TG. After adjusting for independent variables, TC and TG had the same risk with fasting plasma glucose (FPG) and body mass index. Risk factors of TC and LDL-C were women, age and FPG. Mongolia nationality as a protective factor positively correlated with TC, LDL-C, and TG. Women, age, drinking, and classification of blood pressure were protective factors but Mongolia nationality was a risk factor for HDL-C.

CONCLUSIONS

This study demonstrated that the prevalence of dyslipidemia was relatively high among rural hypertensive patients in China and there were many modifiable risk factors for dyslipidemia such as hypertension, weight, and impaired glucose metabolism. To prevent dyslipidemia and to reduce the increasing burden of cardiovascular disease in rural areas with the undeveloped economy of China, the first aim for us is to reduce these risk factors.

摘要

背景

血脂异常在心血管疾病的发生发展中起关键作用,心血管疾病已成为大多数发达国家以及发展中国家的主要死因。本研究旨在调查中国农村高血压成年患者血脂异常的流行病学特征。

方法

2004年至2006年期间,通过整群多级抽样对中国辽宁省农村地区6412名年龄≥35岁的高血压居民(2805名男性,3607名女性)进行了横断面调查。血清脂质水平按照美国国家胆固醇教育计划成人治疗组第三次报告的标准进行评估。

结果

在研究人群中,34.4%的人总胆固醇(TC)临界偏高,16.9%的人TC偏高,8.8%的人高密度脂蛋白胆固醇(HDL-C)偏低。低密度脂蛋白胆固醇(LDL-C)临界偏高、偏高和极高的人群分别为15.7%、3.5%和0.9%。此外,15.9%的人甘油三酯(TG)临界偏高,17.8%的人TG偏高,2.0%的人TG极高。在对自变量进行校正后,TC和TG与空腹血糖(FPG)和体重指数具有相同的风险。TC和LDL-C的危险因素为女性、年龄和FPG。蒙古族作为一个保护因素与TC、LDL-C和TG呈正相关。女性、年龄、饮酒和血压分级是HDL-C的保护因素,但蒙古族是HDL-C的危险因素。

结论

本研究表明,中国农村高血压患者血脂异常患病率相对较高,血脂异常存在许多可改变的危险因素,如高血压、体重和糖代谢受损。为预防血脂异常并减轻中国经济欠发达农村地区心血管疾病日益增加的负担,我们的首要目标是降低这些危险因素。

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