用于灵活生物分子识别的最佳特异性和功能。
Optimal specificity and function for flexible biomolecular recognition.
作者信息
Wang Jin, Xu Li, Wang Erkwang
机构信息
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, People's Republic of China.
出版信息
Biophys J. 2007 Jun 15;92(12):L109-11. doi: 10.1529/biophysj.107.105551. Epub 2007 Apr 6.
Abstract
Biomolecular associations often accompanied by large conformational changes, sometimes folding and unfolding. By exploring an exactly solvable model, we constructed the free energy landscape and established a general framework for studying the biomolecular flexible binding process. We derived an optimal criterion for the specificity and function for flexible biomolecular binding where the binding and conformational folding are coupled.
摘要
生物分子相互作用通常伴随着大的构象变化，有时是折叠和去折叠。通过探索一个精确可解的模型，我们构建了自由能景观，并建立了一个研究生物分子柔性结合过程的通用框架。我们推导了一个用于柔性生物分子结合的特异性和功能的最优标准，其中结合和构象折叠是耦合的。
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