McCammon J A
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093-0365, USA.
Curr Opin Struct Biol. 1998 Apr;8(2):245-9. doi: 10.1016/s0959-440x(98)80046-8.
Specific, noncovalent binding of biomolecules can only be understood by considering structural, thermodynamic, and kinetic issues. The theoretical foundations for such analyses have been clarified in the past year. Computational techniques for both particle-based and continuum models continue to improve and to yield useful insights into an ever wider range of biomolecular systems.
生物分子的特异性非共价结合只有通过考虑结构、热力学和动力学问题才能被理解。过去一年中,此类分析的理论基础已得到阐明。基于粒子模型和连续介质模型的计算技术不断改进,并为越来越多的生物分子系统提供了有用的见解。