Severgina E S, Ponomarev A B
Arkh Patol. 1991;53(7):55-60.
Kidney biopsies from 10 patients with diagnosed insulin-dependent diabetes mellitus of various duration with clinical manifestations of hyperglycemia, increased rate of glomerular filtration, presence or absence of microalbuminuria, were studied morphologically. Gradual increase of kidney alterations was observed: changes of thickness and loosening of basal membrane of glomerular capillaries, its focal homogenization, partial mesangium increase due to the increase of membranous substance and decrease of cellular component. These alterations positively correlate with immunohistochemistry of renal glomeruli. Dynamics of morphological changes does not show a direct connection with the patient age and the duration of diagnosed disease but is stipulated by the presence of one or another antigen of the class II major histocompatibility complex.
对10例确诊为不同病程胰岛素依赖型糖尿病的患者进行肾活检，这些患者均有高血糖临床表现、肾小球滤过率升高，伴有或不伴有微量白蛋白尿，对其进行形态学研究。观察到肾脏病变逐渐加重：肾小球毛细血管基底膜厚度改变及疏松，局灶性均质化，由于膜性物质增加和细胞成分减少导致部分系膜增生。这些改变与肾小球免疫组化呈正相关。形态学变化动态与患者年龄及确诊疾病的病程无直接关联，而是由II类主要组织相容性复合体的一种或另一种抗原的存在所决定。
