Ruggiero R, Niinami H, Pochettino A, Hammond R L, Hooper T L, Lu H P, Anderson D R, Spanta A D, Stephenson L W
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine, Detroit, Michigan.
Artif Organs. 1991 Oct;15(5):350-4. doi: 10.1111/j.1525-1594.1991.tb00740.x.
Skeletal muscle ventricles (SMVs) have been constructed from canine latissimus dorsi muscle and connected to the aorta as aortic diastolic counterpulsators. Presently one dog remains alive and well with an SMV that has been functioning continuously in circulation for 18 months, without evidence of thromboembolic complications. SMVs are able to perform cardiac-type work with an output equal to that of the left ventricle at physiologic preloads, when tested with a mock circulation device in our laboratory. SMVs have been used for right-sided cardiac assist. In acute experiments these ventricles have functioned effectively, bypassing the right side of the heart for up to 8 h. Most recently we have tested SMVs using them chronically to pump blood in the right-sided circulation, and at the time of writing they have been shown to function effectively in this configuration for up to 18 days. SMVs may be used in the future as a method of treating patients with left- or right-sided heart failure.
骨骼肌心室（SMV）已由犬的背阔肌构建而成，并作为主动脉舒张期反搏器与主动脉相连。目前，有一只狗身上的SMV在循环中持续运行了18个月，依然存活且状态良好，没有血栓栓塞并发症的迹象。在我们实验室用模拟循环装置进行测试时，SMV能够在生理预负荷下完成相当于左心室输出量的心脏式工作。SMV已被用于右侧心脏辅助。在急性实验中，这些心室有效地发挥了作用，绕过心脏右侧长达8小时。最近，我们对SMV进行了长期测试，使其在右侧循环中泵血，在撰写本文时，已证明它们在这种配置下能有效运行长达18天。SMV未来可能会被用作治疗左心或右心衰竭患者的一种方法。
