Isoda S, Thomas G A, Nakajima H, Lu H, Hammond R L, Nakajima H O, Walters H L, Stephenson L W
First Department of Surgery, Yokohama City University, Japan.
Artif Organs. 1996 Feb;20(2):114-9. doi: 10.1111/j.1525-1594.1996.tb00711.x.
Skeletal muscle ventricles (SMVs) constructed from electrically conditioned latissimus dorsi muscle (LDM) may become an alternative for assisting the failing heart. Left and right heart circulatory assist using SMVs has been performed successfully in both acute and chronic animal models. The configurations used to connect SMVs to the circulation have included a left atrium to aorta bypass, a left ventricle apex to aorta bypass, aortic counterpulsators, a cavopulmonary bypass, and a right ventricle to pulmonary artery bypass. One SMV used as an aortic counterpulsator functioned effectively in the circulation for more than 27 months. Recent application of the pericardium to the SMV as an inner layer and design changes in the connection of the SMV to the circulation have reduced the risk of thrombus formation and SMV rupture. Although several problems have yet to be solved, the goal of the SMV as a permanent circulatory assist device without the limitation of an external power source seems within reach.
由电刺激的背阔肌构建的骨骼肌心室（SMV）可能成为辅助衰竭心脏的一种替代方案。在急性和慢性动物模型中，使用SMV进行左心和右心循环辅助均已成功实施。用于将SMV连接到循环系统的构型包括左心房至主动脉旁路、左心室心尖至主动脉旁路、主动脉反搏器、腔肺分流术以及右心室至肺动脉旁路。一个用作主动脉反搏器的SMV在循环系统中有效运行了超过27个月。近期将心包用作SMV的内层以及对SMV与循环系统连接的设计改进，降低了血栓形成和SMV破裂的风险。尽管仍有若干问题有待解决，但将SMV作为不受外部电源限制的永久性循环辅助装置的目标似乎触手可及。
