Mirza Ayesha, Wludyka Peter, Chiu Thomas T, Rathore Mobeen H
Pediatric Infectious Diseases and Immunology, University of Florida Health Science Center, Jacksonville, Florida, USA.
Clin Pediatr (Phila). 2007 Apr;46(3):241-6. doi: 10.1177/0009922806290219.
This study was conducted to determine if culture confirmation is needed for a negative rapid antigen detection test. Data on 18,509 tests done in patients younger than 18 years old were reviewed. Of the 14,167 (76.5%) that were negative, 968 (6.8%) were associated with positive cultures. No significant seasonal variation was noted. Significant differences were found between hospital and pediatric practices in the percentage of patients with a negative rapid antigen detection test who actually had group A beta-hemolytic streptococcus (3.5% to 9.8%). This study supports the recommendation of culture confirmation of a negative rapid antigen detection test and validation of results within an individual practice if confirmatory cultures are not being performed. This study showed a high false-negative rate of the negative rapid antigen detection test and variation among hospital and pediatric practices for rates of positive culture after a negative rapid antigen detection test.
本研究旨在确定对于快速抗原检测呈阴性的结果是否需要进行培养确诊。回顾了18509例18岁以下患者的检测数据。在14167例（76.5%）检测结果为阴性的患者中，968例（6.8%）培养结果为阳性。未发现明显的季节性变化。在快速抗原检测呈阴性但实际感染A组β溶血性链球菌的患者比例方面，医院和儿科诊所之间存在显著差异（3.5%至9.8%）。本研究支持对快速抗原检测阴性结果进行培养确诊的建议，以及在不进行确诊培养的情况下在个体医疗机构内对结果进行验证。本研究显示快速抗原检测阴性结果的假阴性率较高，且医院和儿科诊所在快速抗原检测阴性后培养阳性率方面存在差异。
